The proposed project will determine if a relaxation-based stress management training program can have a significant long-term impact on blood glucose control in high Trait Anxious patients with non- insulin dependent diabetes (NIDDM). Men and women with NIDDM will be screened with the Speilberger State Trait Anxiety Inventory (STAI) and, using standardized norms, classified as low or high anxiety individuals. After baseline assessment, 120 patients with high anxiety and 120 patients with low anxiety will be stratified by weight and randomized to either intervention or control condition. Experimental subjects will attend 6 weekly, small group sessions of relaxation-based stress management training and general diabetes education. Control subjects will attend 6 identically scheduled sessions of general diabetes education. Subjects will be followed for 1 year and blood glucose control will be assessed at baseline, 2 months, 6 months and 12 months with measures of: glucose tolerance, glucose stimulated insulin response, mean and variability of self-monitored blood glucose over 1 week and glycated hemoglobin. Assessment of Trait Anxiety, as well as frequency of use of stress management techniques will be made utilizing the STAI at baseline, 2, 6 and 12 months, as well as telephone interview at 4 and 9 months. An exploratory analysis involving Low Trait Anxious subjects will investigate whether patients exhibiting the repressive coping style (characterized by low Trait Anxiety and high Social Desirability) also demonstrate improvements in glucose control with stress management training.
| Surwit, Richard S; van Tilburg, Miranda A L; Zucker, Nancy et al. (2002) Stress management improves long-term glycemic control in type 2 diabetes. Diabetes Care 25:30-4 |
| Lane, J D; McCaskill, C C; Williams, P G et al. (2000) Personality correlates of glycemic control in type 2 diabetes. Diabetes Care 23:1321-5 |
| Collins, S; Daniel, K W; Petro, A E et al. (1997) Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138:405-13 |
| Collins, S; Surwit, R S (1996) Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271:9437-40 |
