Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049221-01A2
Application #
2149873
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1996-06-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Upstate Medical University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
Doherty, Edward; Perl, Andras (2017) Measurement of Mitochondrial Mass by Flow Cytometry during Oxidative Stress. React Oxyg Species (Apex) 4:275-283
Perl, Andras (2016) Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases. Nat Rev Rheumatol 12:169-82
Perl, Andras (2015) mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging. Ann N Y Acad Sci 1346:33-44
Joseph, Nidhin; Zhang-James, Yanli; Perl, Andras et al. (2015) Oxidative Stress and ADHD: A Meta-Analysis. J Atten Disord 19:915-24
Perl, Andras; Hanczko, Robert; Telarico, Tiffany et al. (2011) Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase. Trends Mol Med 17:395-403
Hernández-Negrete, Ivette; Sala-Newby, Graciela B; Perl, Andras et al. (2011) Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF). Biochem J 436:133-43
Niland, Brian; Miklossy, Gabriella; Banki, Katalin et al. (2010) Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol 184:4025-32
Engelke, Udo F H; Zijlstra, Fokje S M; Mochel, Fanny et al. (2010) Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency. Biochim Biophys Acta 1802:1028-35
Hanczko, Robert; Fernandez, David R; Doherty, Edward et al. (2009) Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J Clin Invest 119:1546-57
Perl, Andras (2009) Overview of signal processing by the immune system in systemic lupus erythematosus. Autoimmun Rev 8:177-8

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