Interleukin 6 and Human Biliary Epithelial Proliferation

Demetris, Anthony J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 1R01DK049615-01A1
• Application #: 2150441
• Study Section: Metabolic Pathology Study Section (MEP)
• Project Start: 1996-03-01
• Project End: 2001-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: University of Pittsburgh
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 053785812
• City: Pittsburgh
• State: PA
• Country: United States
• Zip Code: 15213

Publications

Specht, Susan; Isse, Kumiko; Nozaki, Isao et al. (2013) SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis 30:877-90

Demetris, Anthony J; Specht, Susan; Nozaki, Isao et al. (2008) Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. J Hepatol 48:276-88

Lim, Kyu; Han, Chang; Xu, Lihong et al. (2008) Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res 68:553-60

Lunz 3rd, John G; Specht, Susan M; Murase, Noriko et al. (2007) Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology 46:1946-59

Demetris, A J; Fontes, Paulo; Lunz 3rd, John G et al. (2006) Wound healing in the biliary tree of liver allografts. Cell Transplant 15 Suppl 1:S57-65

Demetris, A-J; Lunz 3rd, John-G; Specht, Susan et al. (2006) Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. World J Gastroenterol 12:3512-22

Han, Chang; Demetris, A Jake; Stolz, Donna B et al. (2006) Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway. J Biol Chem 281:24831-46

Toyokawa, Hideyoshi; Nakao, Atsunori; Stolz, Donna B et al. (2006) 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injury. Lab Invest 86:72-82

Demetris, Anthony J; Kelly, Dympna M; Eghtesad, Bijan et al. (2006) Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. Am J Surg Pathol 30:986-93

Nozaki, Isao; Lunz 3rd, John G; Specht, Susan et al. (2005) Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. Lab Invest 85:109-23