Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049715-01A1
Application #
2150600
Study Section
Special Emphasis Panel (ZRG4-TOX-1 (01))
Project Start
1996-06-01
Project End
2000-04-30
Budget Start
1996-06-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Li, Xin; Bratton, Stacie; Radominska-Pandya, Anna (2007) Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes. Drug Metab Pharmacokinet 22:152-61
Xiong, Yan; Bernardi, Dan; Bratton, Stacie et al. (2006) Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis. Biochemistry 45:2322-32
Finel, Moshe; Li, Xin; Gardner-Stephen, Dione et al. (2005) Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity. J Pharmacol Exp Ther 315:1143-9
Chen, Guangping; Zhang, Daqing; Jing, Nin et al. (2003) Human gastrointestinal sulfotransferases: identification and distribution. Toxicol Appl Pharmacol 187:186-97
Radominska-Pandya, Anna; Pokrovskaya, Irina D; Xu, Jing et al. (2002) Nuclear UDP-glucuronosyltransferases: identification of UGT2B7 and UGT1A6 in human liver nuclear membranes. Arch Biochem Biophys 399:37-48
Radominska-Pandya, Anna; Chen, Guangping (2002) Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta. Biochemistry 41:4883-90
Jude, A R; Little, J M; Bull, A W et al. (2001) 13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases. Drug Metab Dispos 29:652-5
Radominska-Pandya, A; Little, J M; Czernik, P J (2001) Human UDP-glucuronosyltransferase 2B7. Curr Drug Metab 2:283-98
Radominska-Pandya, A; Chen, G; Samokyszyn, V M et al. (2001) Application of photoaffinity labeling with [(3)H] all trans- and 9-cis-retinoic acids for characterization of cellular retinoic acid--binding proteins I and II. Protein Sci 10:200-11
Jude, A R; Little, J M; Czernik, P J et al. (2001) Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved. Arch Biochem Biophys 389:176-86

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