Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049771-01A1
Application #
2150676
Study Section
Special Emphasis Panel (ZRG4-GMB (01))
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Abrass, Christine K; Hansen, Kim M; Patton, Bruce L (2010) Laminin alpha4-null mutant mice develop chronic kidney disease with persistent overexpression of platelet-derived growth factor. Am J Pathol 176:839-49
Abrass, Christine K; Hansen, Kim M (2010) Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. J Biol Chem 285:12925-34
Schaeffer, Valerie; Hansen, Kim M; Morris, David R et al. (2010) Reductions in laminin beta2 mRNA translation are responsible for impaired IGFBP-5-mediated mesangial cell migration in the presence of high glucose. Am J Physiol Renal Physiol 298:F314-22
Zager, Richard A; Johnson, Ali C; Lund, Steve et al. (2006) Levosimendan protects against experimental endotoxemic acute renal failure. Am J Physiol Renal Physiol 290:F1453-62
Hansen, Kim; Abrass, Christine K (2003) Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration. Kidney Int 64:110-8
Berfield, Anne K; Andress, Dennis L; Abrass, Christine K (2002) IGF-1-induced lipid accumulation impairs mesangial cell migration and contractile function. Kidney Int 62:1229-37
Berfield, A K; Andress, D L; Abrass, C K (2000) IGFBP-5(201-218) stimulates Cdc42GAP aggregation and filopodia formationin migrating mesangial cells. Kidney Int 57:1991-2003
Hansen, K; Abrass, C K (1999) Role of laminin isoforms in glomerular structure. Pathobiology 67:84-91
Hansen, K M; Berfield, A K; Spicer, D et al. (1998) Rat mesangial cells express two unique isoforms of laminin which modulate mesangial cell phenotype. Matrix Biol 17:117-30
Abrass, C K; Spicer, D; Berfield, A K et al. (1997) Diabetes induces changes in glomerular development and laminin-beta 2 (s-laminin) expression. Am J Pathol 151:1131-40