Abstract

This is a proposal to study the food entrainable circadian oscillator, an important and much neglected aspect of the circadian system. Although we know that there is a food entrainable oscillator which is separate from the light entrainable oscillator that resides in the suprachiasmatic nucleus, we do not know where it is located, nor how signals from the food input pathway reach it and entrain it. The PI proposes a series of experiments to address these areas of ignorance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050224-04
Application #
2749561
Study Section
Special Emphasis Panel (ZRG1-BPO (02))
Program Officer
Yanovski, Susan Z
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Florida State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
020520466
City
Tallahassee
State
FL
Country
United States
Zip Code
32306

  Publications

Aragona, Brandon J; Curtis, J Thomas; Davidson, Alec J et al. (2002) Behavioral and neurochemical investigation of circadian time-place learning in the rat. J Biol Rhythms 17:330-44
Cassone, Vincent M; Stephan, Friedrich K (2002) Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: implications for nutrition during manned space flight. Nutrition 18:814-9
Davidson, A J; Cappendijk, S L; Stephan, F K (2000) Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats. Am J Physiol Regul Integr Comp Physiol 278:R1296-304
Stephan, F K; Smith, J C; Fisher, E (1999) Profound conditioned taste aversion induced by oral consumption of 2-deoxy-D-glucose. Physiol Behav 68:221-6
Davidson, A J; Stephan, F K (1999) Feeding-entrained circadian rhythms in hypophysectomized rats with suprachiasmatic nucleus lesions. Am J Physiol 277:R1376-84
Davidson, A J; Stephan, F K (1999) Plasma glucagon, glucose, insulin, and motilin in rats anticipating daily meals. Physiol Behav 66:309-15
Davidson, A J; Stephan, F K (1998) Circadian food anticipation persists in capsaicin deafferented rats. J Biol Rhythms 13:422-9
Stephan, F K; Davidson, A J (1998) Glucose, but not fat, phase shifts the feeding-entrained circadian clock. Physiol Behav 65:277-88
Stephan, F K (1997) Calories affect zeitgeber properties of the feeding entrained circadian oscillator. Physiol Behav 62:995-1002