Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK050265-01A1
Application #
2151318
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1996-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Vigna, Steven R (2016) Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. Int J Inflam 2016:4705065
McVey, Douglas C; Vigna, Steven R (2005) The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. Gastroenterology 128:1306-16
McVey, Douglas C; Schmid, Patricia C; Schmid, Harald H O et al. (2003) Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). J Pharmacol Exp Ther 304:713-22
Vigna, Steven R (2003) The role of the amino-terminal domain of tachykinins in neurokinin-1 receptor signaling and desensitization. Neuropeptides 37:30-5
Nathan, Jaimie D; Peng, Ruth Y; Wang, Yu et al. (2002) Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol 283:G938-46
McVey, D C; Vigna, S R (2001) The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats. Peptides 22:1439-46
Mantyh, C R; McVey, D C; Vigna, S R (2000) Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats. Neurosci Lett 292:95-8
McVey, D C; Romac, J M; Clay, W C et al. (1999) Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides 20:457-64
Vigna, S R (1999) Phosphorylation and desensitization of neurokinin-1 receptor expressed in epithelial cells. J Neurochem 73:1925-32
Mantyh, C R; Pappas, T N; Lapp, J A et al. (1996) Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology 111:1272-80

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