The Appropriate Blood Pressure Control in Diabetes (ABCD) Trial is a prospective, randomized clinical trial designed to ascertain the effects of moderate versus intensive therapy on the outcome of diabetic complications a normotensive and hypertensive population of type II diabetic subjects. F the purposes of the analyses, the normotensive and the hypertensive populations will be studied independently. The primary outcome measure is glomerular filtration rate (GFR). Secondary outcome measures include retinopathy, urinary albumin excretion (UAE), neuropathy and cardiovascular disease. The secondary aim of the study is to determine if the use of a calcium channel blocker (nisoldipine coat core) will confer equivalent benefits as an angiotensin converting enzyme (ACE) inhibitor (enalapril) wi regards to delaying the onset or diminishing the progression of type II diabetic complications. The trial is currently ongoing with the follow-up 950 randomized subjects. The proposal herein summarizes the design of the trial with the major emphasis on the design, management and operation of th Data Coordinating Center (DCC).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050298-03
Application #
2734208
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1996-07-01
Project End
1999-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Schrier, Robert W; Estacio, Raymond O; Mehler, Philip S et al. (2007) Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial. Nat Clin Pract Nephrol 3:428-38
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Havranek, Edward P; Esler, Anne; Estacio, Raymond O et al. (2003) Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial. Am Heart J 145:993-8
Schrier, Robert W; Estacio, Raymond O; Esler, Anne et al. (2002) Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int 61:1086-97
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Mehler, P S; Jeffers, B W; Biggerstaff, S L et al. (1998) Smoking as a risk factor for nephropathy in non-insulin-dependent diabetics. J Gen Intern Med 13:842-5

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