Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050494-02
Application #
2151505
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1995-05-01
Project End
2000-04-30
Budget Start
1996-05-09
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Chang, Ching-yi; Norris, John D; Jansen, Michelle et al. (2003) Application of random peptide phage display to the study of nuclear hormone receptors. Methods Enzymol 364:118-42
Sathya, Ganesan; Chang, Ching-yi; Kazmin, Dmitri et al. (2003) Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res 63:8029-36
Li, Xiaolin; McDonnell, Donald P (2002) The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol 22:3663-73
Li, Xiaolin; Kimbrel, Erin A; Kenan, Daniel J et al. (2002) Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Mol Endocrinol 16:1482-91
Ito, A; Lai, C H; Zhao, X et al. (2001) p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J 20:1331-40
Hamilton, M H; Tcherepanova, I; Huibregtse, J M et al. (2001) Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 276:26324-31
Chang, C Y; Walther, P J; McDonnell, D P (2001) Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res 61:8712-7
Wagner, B L; Pollio, G; Giangrande, P et al. (1999) The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology 140:1449-58
Wagner, B L; Norris, J D; Knotts, T A et al. (1998) The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol 18:1369-78
Imhof, M O; McDonnell, D P (1996) Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol 16:2594-605

Showing the most recent 10 out of 11 publications