Mechanisms of Intestinal Dysfunction in Simian AIDS

Lackner, Andrew A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK050550-07
• Application #: 6381026
• Study Section: Special Emphasis Panel (ZRG1-AARR-2 (01))
• Program Officer: Hamilton, Frank A
• Project Start: 1995-09-30
• Project End: 2001-09-30
• Budget Start: 2001-09-01
• Budget End: 2001-09-30
• Support Year: 7
• Fiscal Year: 2001
• Total Cost: $76,329

Institution

• Name: Harvard University
• Department: Veterinary Sciences
• Type: Schools of Medicine
• DUNS #: 082359691
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Mohan, Mahesh; Kaushal, Deepak; Aye, Pyone P et al. (2013) Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection. PLoS One 8:e60122

Mohan, Mahesh; Kaushal, Deepak; Aye, Pyone P et al. (2012) Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction. PLoS One 7:e34561

Lackner, Andrew A; Mohan, Mahesh; Veazey, Ronald S (2009) The gastrointestinal tract and AIDS pathogenesis. Gastroenterology 136:1965-78

Mohan, Mahesh; Aye, Pyone P; Borda, Juan T et al. (2008) CCAAT/enhancer binding protein beta is a major mediator of inflammation and viral replication in the gastrointestinal tract of simian immunodeficiency virus-infected rhesus macaques. Am J Pathol 173:106-18

Garza, A; Lackner, A; Aye, P et al. (2008) Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol 37:109-15

Mohan, Mahesh; Aye, Pyone P; Borda, Juan T et al. (2007) Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway. Am J Pathol 171:1952-65

Hernandez, Julio; Lackner, Andrew; Aye, Pyone et al. (2007) Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun 75:1137-43

Ramesh, Geeta; Alvarez, Xavier; Borda, Juan T et al. (2005) Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation. Clin Diagn Lab Immunol 12:192-7

Freeman, Lisa M; Mansfield, Keith G; Goldin, Barry et al. (2004) Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaque. J Infect Dis 189:2010-5

Yang, Gui-Bo; Lackner, Andrew A (2004) Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity. J Neuroimmunol 146:46-9