Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050662-02
Application #
2608469
Study Section
Special Emphasis Panel (ZRG2-GMA-2 (01))
Program Officer
Laughlin, Maren R
Project Start
1996-12-18
Project End
1999-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Cunningham, Barbara A; Richard, Ann-Marie T; Dillon, Joseph S et al. (2003) Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J 369:173-8
Yaney, Gordon C; Fairbanks, Jamison M; Deeney, Jude T et al. (2002) Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab 283:E880-8
Yaney, G C; Civelek, V N; Richard, A M et al. (2001) Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes 50:56-62
Corkey, B E; Deeney, J T; Yaney, G C et al. (2000) The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr 130:299S-304S
Farfari, S; Schulz, V; Corkey, B et al. (2000) Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49:718-26
Yaney, G C; Korchak, H M; Corkey, B E (2000) Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology 141:1989-98
Segall, L; Lameloise, N; Assimacopoulos-Jeannet, F et al. (1999) Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am J Physiol 277:E521-8
Zawalich, W S; Bonnet-Eymard, M; Zawalich, K C et al. (1998) Chronic exposure to TPA depletes PKC alpha and augments Ca-dependent insulin secretion from cultured rat islets. Am J Physiol 274:C1388-96
Branstrom, R; Leibiger, I B; Leibiger, B et al. (1998) Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel. J Biol Chem 273:31395-400
Branstrom, R; Corkey, B E; Berggren, P O et al. (1997) Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells. J Biol Chem 272:17390-4