Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK051091-07A2S1
Application #
6803815
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Akolkar, Beena
Project Start
1996-06-01
Project End
2006-11-30
Budget Start
2003-02-01
Budget End
2003-11-30
Support Year
7
Fiscal Year
2003
Total Cost
$8,325
Indirect Cost
Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Rottembourg, Diane; Filippi, Christophe M; Bresson, Damien et al. (2010) Essential role for TLR9 in prime but not prime-boost plasmid DNA vaccination to activate dendritic cells and protect from lethal viral infection. J Immunol 184:7100-7
Bresson, Damien; Fradkin, Matthew; Manenkova, Yulia et al. (2010) Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther 18:307-16
Horwitz, Marshall S; Efrat, Shimon; Christen, Urs et al. (2009) Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes. Proc Natl Acad Sci U S A 106:19450-4
Bresson, D; von Herrath, M (2007) Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmun Rev 6:315-22
Barral, Ana Maria; Thomas, Helen E; Ling, Eleanor M et al. (2006) SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes. J Autoimmun 27:166-73
Filippi, Christophe; von Herrath, Matthias (2005) How viral infections affect the autoimmune process leading to type 1 diabetes. Cell Immunol 233:125-32
Haase, Claus; Ejrnaes, Mette; Juedes, Amy E et al. (2005) Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo. Blood 106:4225-33