Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK051630-01
Application #
2152682
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Worrell, Roger T; Merk, Lisa; Matthews, Jeffrey B (2008) Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1. Am J Physiol Gastrointest Liver Physiol 294:G429-40
Del Castillo, Isabel Calvo; Fedor-Chaiken, Mary; Song, J Cecilia et al. (2005) Dynamic regulation of Na(+)-K(+)-2Cl(-) cotransporter surface expression by PKC-{epsilon} in Cl(-)--secretory epithelia. Am J Physiol Cell Physiol 289:C1332-42
Li, Hong C; Szigligeti, Peter; Worrell, Roger T et al. (2005) Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis. Am J Physiol Renal Physiol 289:F61-71
Worrell, Roger T; Best, Alison; Crawford, Oscar R et al. (2005) Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent. Am J Physiol Gastrointest Liver Physiol 289:G768-78
Li, Hong C; Worrell, Roger T; Matthews, Jeffrey B et al. (2004) Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane. J Biol Chem 279:43190-7
Lotz, Margaret M; Wang, Helen; Song, Jaekyung Cecilia et al. (2004) K+ channel inhibition accelerates intestinal epithelial cell wound healing. Wound Repair Regen 12:565-74
Silva, Milton; Song, Cecilia; Nadeau, William J et al. (2004) Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-alpha-dependent signal transduction pathway. Am J Physiol Gastrointest Liver Physiol 286:G1024-31
Worrell, Roger T; Oghene, Jennifer; Matthews, Jeffrey B (2004) Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. Am J Physiol Gastrointest Liver Physiol 286:G14-22
Mayol, Julio M; Alarma-Estrany, Pilar; O'Brien, Timothy C et al. (2003) Electrogenic ion transport in mammalian colon involves an ammonia-sensitive apical membrane K+ conductance. Dig Dis Sci 48:116-25
Yoo, James; Nichols, Anthony; Song, Jaekyung C et al. (2003) Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes. Am J Physiol Gastrointest Liver Physiol 284:G703-12

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