Abstract

The ultimate goal of this proposal is to develop strategies to prevent allograft rejection by local immunosuppression, using the islet transplant system is chosen. As in their previous submission, the investigators plan to determine whether gene transfer into islets is a feasible approach for local delivery of immunosuppressants. For this purpose, they plan to test the effect of gene transfer into islets and will measure prolongation of islet allograft survival. The genes they plan to transfer include CTLA4-Ig, IL-2-Ig, and CD2-Ig.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052019-04
Application #
6177665
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Harmon, Joan T
Project Start
1997-09-15
Project End
2001-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$200,711
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215