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Leech, Colin A; Chepurny, Oleg G; Holz, George G (2010) Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitam Horm 84:279-302
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Holz, George G (2004) Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 53:5-13
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Holz, George G; Chepurny, Oleg G (2003) Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem 10:2471-83
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Kang, Guoxin; Holz, George G (2003) Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells. J Physiol 546:175-89
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Kang, Guoxin; Joseph, Jamie W; Chepurny, Oleg G et al. (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 278:8279-85
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Chepurny, Oleg G; Hussain, Mehboob A; Holz, George G (2002) Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220. Endocrinology 143:2303-13
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Chepurny, Oleg G; Holz, George G (2002) Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell Tissue Res 307:191-201
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Kang, G; Chepurny, O G; Holz, G G (2001) cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells. J Physiol 536:375-85
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Skoglund, G; Hussain, M A; Holz, G G (2000) Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element. Diabetes 49:1156-64
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Holz, G G; Leech, C A; Habener, J F (2000) Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells. Biochimie 82:915-26
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Showing the most recent 10 out of 13 publications
