The objective of this application is to dissect the structure-function relationships of CREB binding protein, CBP. It is proposed to 1) characterize the domains of CBP which activate transcription; 2) characterize the structural domains within the activation domains of CBP; 3) identify the core transcriptional molecules which interact with CBP; and, 4) determine the domains within CBP which are required for E1A repression of CBP-mediated transcription.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052231-03
Application #
2872236
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Margolis, Ronald N
Project Start
1997-02-01
Project End
2001-01-31
Budget Start
1999-02-15
Budget End
2000-01-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103