Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
9R01DK052232-06
Application #
2152832
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1990-07-01
Project End
2000-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Shimizu, Yoshiaki; Margenthaler, Julie A; Landeros, Keith et al. (2002) The resistance of P. acnes--primed interferon gamma-deficient mice to low-dose lipopolysaccharide-induced acute liver injury. Hepatology 35:805-14
Genden, E M; Mackinnon, S E; Yu, S et al. (2001) Pretreatment with portal venous ultraviolet B-irradiated donor alloantigen promotes donor-specific tolerance to rat nerve allografts. Laryngoscope 111:439-47
Genden, E M; Mackinnon, S E; Yu, S et al. (2001) Portal venous ultraviolet B-irradiated donor alloantigen prevents rejection in circumferential rat tracheal allografts. Otolaryngol Head Neck Surg 124:481-8
Otomo, N; Margenthaler, J A; Motoyama, K et al. (2001) Organ transplant specificity of tolerance to skin grafts with heart or kidney grafts plus nondepleting anti-CD4 monoclonal antibody (RIB 5/2) and intravenous donor alloantigen administration. J Surg Res 98:59-65
Otomo, N; Motoyama, K; Yu, S et al. (2001) Intrathymic alloantigen-mediated tolerant, completely MHC-mismatched mouse hearts are specifically rejected by adoptively transferred in vitro-sensitized anti-class I L(d+)-specific 2C cells. Transplant Proc 33:159-60
Shimizu, Y; Otomo, N; Yu, S et al. (2001) Donor-specific antigen transfusion-mediated cardiac allograft tolerance is prevented by prior treatment with anti-CD8, but not anti-CD4, antibody. Transplant Proc 33:150-1
Motoyama, K; Arima, T; Yu, S et al. (2000) The kinetics of tolerance induction by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) plus intravenous donor alloantigen administration. Transplantation 69:285-93
Smith, C R; Mohanakumar, T; Shimizu, Y et al. (2000) Brief cyclosporine treatment prevents intrathymic (IT) tolerance induction and precipitates acute rejection in an IT rat cardiac allograft model. Transplantation 69:294-9
Otomo, N; Motoyama, K; Yu, S et al. (2000) Intrathymic alloantigen-mediated, tolerant, completely major histocompatibility complex-mismatched mouse hearts are specifically rejected by adoptively transferred anti-class I L(d+)-specific 2C cells. Surgery 128:206-12
Motoyama, K; Lehmann, M; Flye, M W (1999) Analysis of donor-specific unresponsiveness to rat allografts by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) plus donor antigen. Transplant Proc 31:1237-8

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