Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK052596-01A1S1
Application #
2719610
Study Section
Special Emphasis Panel (ZRG4 (01))
Project Start
1997-09-30
Project End
2000-08-31
Budget Start
1998-02-10
Budget End
1998-08-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Kim, Jayoung; Keay, Susan K; You, Sungyong et al. (2012) A synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2. PLoS One 7:e50392
Yang, Wei; Kim, Yongsoo; Kim, Taek-Kyun et al. (2012) Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. BJU Int 110:E1138-46
Kim, Jayoung; Ji, Mihee; DiDonato, Joseph A et al. (2011) An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor. In Vitro Cell Dev Biol Anim 47:2-9
Yang, Wei; Chung, Yeun Goo; Kim, Yongsoo et al. (2011) Quantitative proteomics identifies a beta-catenin network as an element of the signaling response to Frizzled-8 protein-related antiproliferative factor. Mol Cell Proteomics 10:M110.007492
Keay, Susan; Kaczmarek, Piotr; Zhang, Chen-Ou et al. (2011) Normalization of proliferation and tight junction formation in bladder epithelial cells from patients with interstitial cystitis/painful bladder syndrome by d-proline and d-pipecolic acid derivatives of antiproliferative factor. Chem Biol Drug Des 77:421-30
Kim, Jayoung; Keay, Susan K; Freeman, Michael R (2009) Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. BJU Int 103:541-6
Sun, Yan; Keay, Susan; Lehrfeld, Todd J et al. (2009) Changes in adenosine triphosphate-stimulated ATP release suggest association between cytokine and purinergic signaling in bladder urothelial cells. Urology 74:1163-8
Planey, Sonia L; Keay, Susan K; Zhang, Chen-Ou et al. (2009) Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. Mol Biol Cell 20:1454-63
Kaczmarek, Piotr; Keay, Susan K; Tocci, Gillian M et al. (2008) Structure-activity relationship studies for the peptide portion of the bladder epithelial cell antiproliferative factor from interstitial cystitis patients. J Med Chem 51:5974-83
Kim, Jayoung; Keay, Susan K; Dimitrakov, Jordan D et al. (2007) p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett 581:3795-9

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