Abstract

In this second revised submission, the applicant details studies to examine mechanisms regulating vascularization of the normal prostate. Based on consideration that: (a) prostatic vascularity is androgen modulated, and (b) endothelial cells lack androgen receptors, the applicant proposes that androgen-mediated prostatic angiogenesis is indirectly effected by the potent angiogenic factor, vascular endothelial growth factor (VEGF). It is believed that expression of VEGF is androgen-modulated in non-endothelial prostatic cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052644-04
Application #
6381346
Study Section
Special Emphasis Panel (ZRG4-UROL (01))
Program Officer
Mullins, Christopher V
Project Start
1998-09-28
Project End
2004-07-31
Budget Start
2001-08-01
Budget End
2004-07-31
Support Year
4
Fiscal Year
2001
Total Cost
$240,339
Indirect Cost

  Institution

Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Bates, Michael; Kovalenko, Bruce; Wilson, E Lynette et al. (2008) Endothelial cells support the growth of prostate tissue in vivo. Prostate 68:893-901
Wang, Gui-Min; Kovalenko, Bruce; Huang, Yili et al. (2007) Vascular endothelial growth factor and angiopoietin are required for prostate regeneration. Prostate 67:485-99
Wang, Gui-Min; Kovalenko, Bruce; Wilson, E Lynette et al. (2007) Vascular density is highest in the proximal region of the mouse prostate. Prostate 67:968-75
Roghani, Monireh; Moscatelli, David (2007) Prostate cells express two isoforms of fibroblast growth factor receptor 1 with different affinities for fibroblast growth factor-2. Prostate 67:115-24
Richard, Christian; Kim, Gilbert; Koikawa, Yasuhiro et al. (2002) Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells. Prostate 50:83-91
Richard, C; Roghani, M; Moscatelli, D (2000) Fibroblast growth factor (FGF)-2 mediates cell attachment through interactions with two FGF receptor-1 isoforms and extracellular matrix or cell-associated heparan sulfate proteoglycans. Biochem Biophys Res Commun 276:399-405