Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052920-05
Application #
6381407
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Serrano, Jose
Project Start
1997-09-01
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2003-08-31
Support Year
5
Fiscal Year
2001
Total Cost
$146,000
Indirect Cost
Name
Ohio State University
Department
Surgery
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Lunsford, K E; Horne, P H; Koester, M A et al. (2006) Activation and maturation of alloreactive CD4-independent, CD8 cytolytic T cells. Am J Transplant 6:2268-81
Horne, Phillip H; Lunsford, Keri E; Eiring, Anna M et al. (2005) CD4+ T-cell-dependent immune damage of liver parenchymal cells is mediated by alloantibody. Transplantation 80:514-21
Lunsford, Keri E; Koester, Mitchel A; Eiring, Anna M et al. (2005) Targeting LFA-1 and cd154 suppresses the in vivo activation and development of cytolytic (cd4-Independent) CD8+ T cells. J Immunol 175:7855-66
Lunsford, Keri E; Gao, Donghong; Eiring, Anna M et al. (2004) Evidence for tissue-directed immune responses: analysis of CD4- and CD8-dependent alloimmunity. Transplantation 78:1125-33
Gao, Donghong; Lunsford, Keri E; Eiring, Anna M et al. (2004) Critical role for CD8 T cells in allograft acceptance induced by DST and CD40/CD154 costimulatory blockade. Am J Transplant 4:1061-70
Wang, Yue; Gao, Donghong; Lunsford, Keri E et al. (2003) Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection. Am J Transplant 3:1251-8
Bumgardner, Ginny L; Gao, Donghong; Li, Jiashun et al. (2002) MHC-identical heart and hepatocyte allografts evoke opposite immune responses within the same host. Transplantation 74:855-64
Gao, D; Li, J; Orosz, C G et al. (2000) Different costimulation signals used by CD4(+) and CD8(+) cells that independently initiate rejection of allogenic hepatocytes in mice. Hepatology 32:1018-28
Bumgardner, G L; Orosz, C G (2000) Unusual patterns of alloimmunity evoked by allogeneic liver parenchymal cells. Immunol Rev 174:260-79
Bumgardner, G L; Gao, D; Li, J et al. (2000) Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70:1771-80

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