Abstract

This grant has three Specific Aims: Electrophysiologic studies of the activated Na+ channel phenotype in B lymphocytes from patients with hypertension, the expression of the Na+ channel phenotype in the oocyte expression system, and expression studies and cloning of the B lymphocyte Na+ channel subunits.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK053161-04
Application #
6178131
Study Section
Special Emphasis Panel (ZRG4-GMB (04))
Program Officer
Scherbenske, M James
Project Start
1997-05-01
Project End
2003-04-30
Budget Start
2000-05-01
Budget End
2003-04-30
Support Year
4
Fiscal Year
2000
Total Cost
$277,175
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Ma, He-Ping; Al-Khalili, Otor; Ramosevac, Semra et al. (2004) Steroids and exogenous gamma-ENaC subunit modulate cation channels formed by alpha-ENaC in human B lymphocytes. J Biol Chem 279:33206-12
Ma, He-Ping; Li, Li; Zhou, Zhen-Hong et al. (2002) ATP masks stretch activation of epithelial sodium channels in A6 distal nephron cells. Am J Physiol Renal Physiol 282:F501-5
Warnock, D G (2001) Genetic forms of human hypertension. Curr Opin Nephrol Hypertens 10:493-9
Warnock, D G (2001) Prevention, protection, and the intrarenal renin-angiotensin systems. Semin Nephrol 21:593-602
Meneton, P G; Warnock, D (2001) Involvement of renal apical Na transport systems in the control of blood pressure. Am J Kidney Dis 37:S39-47
Oh, Y S; Lee, S; Won, C et al. (2001) An Alu cassette in the human epithelial sodium channel. Biochim Biophys Acta 1520:94-8
Saxena, S; Quick, M W; Warnock, D G (2000) Interaction of syntaxins with epithelial ion channels. Curr Opin Nephrol Hypertens 9:523-7
Oh, Y S; Warnock, D G (2000) Disorders of the epithelial Na(+) channel in Liddle's syndrome and autosomal recessive pseudohypoaldosteronism type 1. Exp Nephrol 8:320-5
Warnock, D G (2000) Aldosterone-related genetic effects in hypertension. Curr Hypertens Rep 2:295-301
Warnock, D G (1999) Hypertension. Semin Nephrol 19:374-80

Showing the most recent 10 out of 14 publications