Abstract

Retinoids regulate a remarkably broad range of biological processes in both developing and adult individuals. The diversity of these effects is matched by the functional complexity of the retinoid receptors. The three types of retinoic acid receptors (RARs) and three types of retinoid X receptors (RXRs) bind at least five distinct types of retinoic acid response elements (RAREs) as either RAR/RXR heterodimers or RXR homodimers. The investigators have recently expanded the diversity of the retinoid response by identifying RIP14 as a seventh retinoid-activated receptor. We hypothesize that RIP14 plays an important, tissue-specific role in retinoid signaling and propose 4 specific aims to further characterize its activities and test this hypothesis. 1) The RIP14 gene will be isolated, and the molecular basis for the expression of the RIP14 isoforms determined. 2) RIP 14 DNA binding sites will be characterized in detail and their ability to confer response to individual isoforms will be defined. 3) The response of the PLTP gene to RIP14 will be critically tested, and other potential RIP14 targets will be identified and characterized. 4) ES cell lines defective in the RIP14 gene will be generated and used to create mice deficient in RIP14.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK053366-03
Application #
6177784
Study Section
Endocrinology Study Section (END)
Program Officer
Margolis, Ronald N
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
3
Fiscal Year
2000
Total Cost
$239,579
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Jung, Dongju; York, J Philippe; Wang, Li et al. (2014) FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. Pflugers Arch 466:1011-9
Xia, Xuefeng; Jung, Dongju; Webb, Paul et al. (2012) Liver X receptor ýý and peroxisome proliferator-activated receptor ýý regulate cholesterol transport in murine cholangiocytes. Hepatology 56:2288-96
Li, Yilan; Ross-Viola, Jennifer S; Shay, Neil F et al. (2009) Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr 139:898-904
Del Bas, Josep Maria; Ricketts, Marie-Louise; Vaqué, Montserrat et al. (2009) Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Mol Nutr Food Res 53:805-14
Zhang, Lisheng; Huang, Xiongfei; Meng, Zhipeng et al. (2009) Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol 23:137-45
Ricketts, Marie-Louise; Boekschoten, Mark V; Kreeft, Arja J et al. (2007) The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol 21:1603-16
Yang, Fan; Huang, Xiongfei; Yi, Tangsheng et al. (2007) Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 67:863-7
Wang, Li; Huang, Jiansheng; Saha, Pradip et al. (2006) Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol 20:2671-81
Ma, Ke; Saha, Pradip K; Chan, Lawrence et al. (2006) Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 116:1102-9
Huang, Wendong; Ma, Ke; Zhang, Jun et al. (2006) Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312:233-6

Showing the most recent 10 out of 17 publications