Irritable Bowel Syndrome (IBS) is a widespread, chronic, disorder of the lower gastrointestinal tract which seems relatively refractory to standard medical care. Recent research from our laboratory strongly suggests that cognitive therapy (CT) is highly effective (70-80 percent clinically improved) in the short-term (out to 3 months post-treatment). The current application seeks to replicate and extend our previous small-scale studies by conducting a controlled clinical trial of CT vs. a self-help support group as an attention placebo control and symptoms monitoring wait list of 240 chronic IBS patients and follow up the treated patients for at least 12 months. To complete the project in a timely fashion a second site, University of Buffalo Medical Scholl, will be added to run half of the sample. Within this overall project 5 studies will be conducted: (a) examination of relations between stress, especially minor stressful events, and IBS symptoms; (b) controlled comparison of brief (10 sessions) CT administered in small groups to (SG) and to (sic) symptom monitoring. The latter will subsequently be treated to increase the sample sizes for studies c, d, and e; (c) identification of the processes of change within the CT treatment of IBS by examining, at various levels of analysis, the relations between changes in cognitive variables and changes in GI symptoms; (d) prospective one-year follow-up of the effect of CT and SG on IBS; (e) prediction algorithm for the results of the CT treatment of IBS from variables derived from the careful pretreatment assessment of participants; we will determine prediction schemes of end of treatment and a 3-month follow-up as well as what variables predict maintenance of symptom relief over the 12 month follow-up.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK054211-01A1
Application #
2900343
Study Section
Behavioral Medicine Study Section (BEM)
Program Officer
Robuck, Patricia R
Project Start
1999-09-01
Project End
2003-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
State University of New York at Albany
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12222
Freidenberg, Brian M; Gusmano, Rebecca; Hickling, Edward J et al. (2010) Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: a preliminary study. Physiol Behav 99:234-6
Lackner, Jeffrey M; Jaccard, James; Krasner, Susan S et al. (2007) How does cognitive behavior therapy for irritable bowel syndrome work? A mediational analysis of a randomized clinical trial. Gastroenterology 133:433-44
Blanchard, Edward B; Lackner, Jeffrey M; Sanders, Kathryn et al. (2007) A controlled evaluation of group cognitive therapy in the treatment of irritable bowel syndrome. Behav Res Ther 45:633-48
Lackner, Jeffrey M; Gudleski, Gregory D; Zack, Matthew M et al. (2006) Measuring health-related quality of life in patients with irritable bowel syndrome: can less be more? Psychosom Med 68:312-20
Blanchard, Edward B; Lackner, Jeffrey M; Gusmano, Rebecca et al. (2006) Prediction of treatment outcome among patients with irritable bowel syndrome treated with group cognitive therapy. Behav Res Ther 44:317-37
Lackner, Jeffrey M; Jaccard, James; Blanchard, Edward B (2005) Testing the sequential model of pain processing in irritable bowel syndrome: a structural equation modeling analysis. Eur J Pain 9:207-18
Lackner, Jeffrey M; Quigley, Brian M (2005) Pain catastrophizing mediates the relationship between worry and pain suffering in patients with irritable bowel syndrome. Behav Res Ther 43:943-57
Lackner, Jeffrey M; Gurtman, Michael B (2005) Patterns of interpersonal problems in irritable bowel syndrome patients: a circumplex analysis. J Psychosom Res 58:523-32
Lackner, Jeffrey M; Gudleski, Gregory D; Blanchard, Edward B (2004) Beyond abuse: the association among parenting style, abdominal pain, and somatization in IBS patients. Behav Res Ther 42:41-56
Lackner, Jeffrey M; Gurtman, Michael B (2004) Pain catastrophizing and interpersonal problems: a circumplex analysis of the communal coping model. Pain 110:597-604

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