Abstract

Chemists and physicians at the University of Pittsburgh will together develop a novel, recently invented glucose sensing group of materials based on the Intelligent Polymerized Crystalline Colloidal Array (IPCCA) chemical sensor technology. They will develop a novel, sensitive and practical in vivo sensing device to continuously monitor the ambient glucose concentrations. The work will involve 1) fundamental studies of the sensing mechanisms of the IPCCA; 2) development of new sensing motifs based on the IPCCA materials; 3) optimization of the sensing response of in vivo use; 4) demonstrations of the utility of these devices for both subcutaneous and extraocular glucose sensing in normal and alloxan diabetic rabbits. This work will advance this sensing technology to the point it can be further developed as an inexpensive, simple, continuous glucose sensor for use in humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK055348-02
Application #
2906388
Study Section
Special Emphasis Panel (ZRG7-SSS-8 (45))
Program Officer
Harmon, Joan T
Project Start
1998-09-30
Project End
2000-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Taormina, Christopher R; Baca, Justin T; Asher, Sanford A et al. (2007) Analysis of tear glucose concentration with electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 18:332-6
Baca, Justin T; Taormina, Christopher R; Feingold, Eleanor et al. (2007) Mass spectral determination of fasting tear glucose concentrations in nondiabetic volunteers. Clin Chem 53:1370-2
Kimble, Kyle W; Walker, Jeremy P; Finegold, David N et al. (2006) Progress toward the development of a point-of-care photonic crystal ammonia sensor. Anal Bioanal Chem 385:678-85
Walker, Jeremy P; Asher, Sanford A (2005) Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Anal Chem 77:1596-600
Goponenko, Alexander V; Asher, Sanford A (2005) Modeling of stimulated hydrogel volume changes in photonic crystal Pb2+ sensing materials. J Am Chem Soc 127:10753-9
Geary, Caroline D; Zudans, Imants; Goponenko, Alexander V et al. (2005) Electrochemical investigation of Pb2+ binding and transport through a polymerized crystalline colloidal array hydrogel containing benzo-18-crown-6. Anal Chem 77:185-92
Sharma, Anjal C; Jana, Tushar; Kesavamoorthy, Rasu et al. (2004) A general photonic crystal sensing motif: creatinine in bodily fluids. J Am Chem Soc 126:2971-7
Alexeev, Vladimir L; Das, Sasmita; Finegold, David N et al. (2004) Photonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid. Clin Chem 50:2353-60
Asher, Sanford A; Weissman, Jesse M; Tikhonov, Alexander et al. (2004) Diffraction in crystalline colloidal-array photonic crystals. Phys Rev E Stat Nonlin Soft Matter Phys 69:066619
Reese, Chad E; Asher, Sanford A (2003) Photonic crystal optrode sensor for detection of Pb2+ in high ionic strength environments. Anal Chem 75:3915-8

Showing the most recent 10 out of 12 publications