Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK055719-04S1
Application #
6802932
Study Section
Physical Biochemistry Study Section (PB)
Program Officer
Mckeon, Catherine T
Project Start
1999-04-15
Project End
2004-09-30
Budget Start
2002-04-01
Budget End
2004-09-30
Support Year
4
Fiscal Year
2003
Total Cost
$89,400
Indirect Cost
Name
Oregon Health and Science University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Morgan, Clinton T; Tsivkovskii, Ruslan; Kosinsky, Yuri A et al. (2004) The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F. J Biol Chem 279:36363-71
Lutsenko, S; Petris, M J (2003) Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches. J Membr Biol 191:1-12
Huster, Dominik; Lutsenko, Svetlana (2003) The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein. J Biol Chem 278:32212-8
Lutsenko, Svetlana; Tsivkovskii, Ruslan; Walker, Joel M (2003) Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1. Ann N Y Acad Sci 986:204-11
Tsivkovskii, Ruslan; Efremov, Roman G; Lutsenko, Svetlana (2003) The role of the invariant His-1069 in folding and function of the Wilson's disease protein, the human copper-transporting ATPase ATP7B. J Biol Chem 278:13302-8
Vanderwerf, S M; Lutsenko, S (2002) The Wilson's disease protein expressed in Sf9 cells is phosphorylated. Biochem Soc Trans 30:739-41
Lutsenko, Svetlana; Efremov, Roman G; Tsivkovskii, Ruslan et al. (2002) Human copper-transporting ATPase ATP7B (the Wilson's disease protein): biochemical properties and regulation. J Bioenerg Biomembr 34:351-62
Walker, Joel M; Tsivkovskii, Ruslan; Lutsenko, Svetlana (2002) Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity. J Biol Chem 277:27953-9
Tsivkovskii, Ruslan; Eisses, John F; Kaplan, Jack H et al. (2002) Functional properties of the copper-transporting ATPase ATP7B (the Wilson's disease protein) expressed in insect cells. J Biol Chem 277:976-83
Vanderwerf, S M; Cooper, M J; Stetsenko, I V et al. (2001) Copper specifically regulates intracellular phosphorylation of the Wilson's disease protein, a human copper-transporting ATPase. J Biol Chem 276:36289-94