Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK057082-11
Application #
6177716
Study Section
Endocrinology Study Section (END)
Program Officer
Margolis, Ronald N
Project Start
1989-06-01
Project End
2002-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
11
Fiscal Year
2000
Total Cost
$209,282
Indirect Cost

  Institution

Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Fox, Emily M; Andrade, Josefa; Shupnik, Margaret A (2009) Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids 74:622-7
Wen, J; Li, R; Lu, Y et al. (2009) Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions. Oncogene 28:575-86
Fox, Emily M; Bernaciak, Teresa M; Wen, Jie et al. (2008) Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol Endocrinol 22:1781-96
Fox, Emily M; Davis, Rebecca J; Shupnik, Margaret A (2008) ERbeta in breast cancer--onlooker, passive player, or active protector? Steroids 73:1039-51
Silva, Corinne M; Shupnik, Margaret A (2007) Integration of steroid and growth factor pathways in breast cancer: focus on signal transducers and activators of transcription and their potential role in resistance. Mol Endocrinol 21:1499-512
Bryant, Winnifred M; Gibson, Matthew A; Shupnik, Margaret A (2006) Stimulation of the novel estrogen receptor-alpha intronic TERP-1 promoter by estrogens, androgen, pituitary adenylate cyclase-activating peptide, and forskolin, and autoregulation by TERP-1 protein. Endocrinology 147:543-51
Boerner, Julie L; Gibson, Matthew A; Fox, Emily M et al. (2005) Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. Mol Endocrinol 19:2660-70
Bryant, Winnifred; Snowhite, Allison E; Rice, Laurel W et al. (2005) The estrogen receptor (ER)alpha variant Delta5 exhibits dominant positive activity on ER-regulated promoters in endometrial carcinoma cells. Endocrinology 146:751-9
Tsai, Houng-Wei; Katzenellenbogen, John A; Katzenellenbogen, Benita S et al. (2004) Protein kinase A activation of estrogen receptor alpha transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation. Endocrinology 145:2730-8
Lin, Vicky Y; Resnick, Eileen M; Shupnik, Margaret A (2003) Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins. J Biol Chem 278:38125-31

Showing the most recent 10 out of 16 publications