This study proposes to continue follow-up of a cohort of patients with new onset ESRD who were recruited between 1995 and 1998. The purpose of the project now shifts from comparing outcomes between hemodialysis and peritoneal dialysis patients (the aim of the original project) to studying of the relation between a variety of process measures and patient outcomes. Outcomes include mortality, quality of life, patient satisfaction, and development of comorbid conditions. The primary study cohort consists of patients cared for by a chain of non-profit dialysis centers (80 participating centers). This chain has an ongoing research relationship with the study investigators and with the parent institution, Johns Hopkins. Annual self- administered patient surveys and chart review will provide most of the outcomes information and some data on care processes. The principal source of information on care processes, however, will be an annual survey sent to the directors of the 80 participating centers inquiring about a wide variety of care practices. Several hypotheses relating processes to outcomes are given in the specific aims section. The investigators also propose to conduct ancillary, confirmatory analyses using automated data but no primary data collection in a much larger cohort of prevalent cases from these same centers. The same director survey will provide information on care processes as predictors. Outcomes are limited to survival.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
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Study Section
Health Care Quality and Effectiveness Research (HQER)
Program Officer
Eggers, Paul Wayne
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Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
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Banerjee, Tanushree; Meyer, Timothy W; Shafi, Tariq et al. (2017) Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO. Medicine (Baltimore) 96:e5799
Shafi, Tariq; Powe, Neil R; Meyer, Timothy W et al. (2017) Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients. J Am Soc Nephrol 28:321-331
Shafi, Tariq; Hostetter, Thomas H; Meyer, Timothy W et al. (2017) Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis 70:48-58
Kruzan, Rachel M; Herzog, Charles A; Wu, Aozhou et al. (2016) Association of NTproBNP and cTnI with outpatient sudden cardiac death in hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) study. BMC Nephrol 17:18
Scialla, Julia J; Parekh, Rulan S; Eustace, Joseph A et al. (2015) Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis. Am J Nephrol 42:25-34
Shafi, Tariq; Meyer, Timothy W; Hostetter, Thomas H et al. (2015) Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators. PLoS One 10:e0126048
Banerjee, Tanushree; Kim, S Joseph; Astor, Brad et al. (2014) Vascular access type, inflammatory markers, and mortality in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am J Kidney Dis 64:954-61
Scialla, Julia J; Kao, W H Linda; Crainiceanu, Ciprian et al. (2014) Biomarkers of vascular calcification and mortality in patients with ESRD. Clin J Am Soc Nephrol 9:745-55
Shafi, Tariq; Zager, Philip G; Sozio, Stephen M et al. (2014) Troponin I and NT-proBNP and the association of systolic blood pressure with outcomes in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study. Am J Kidney Dis 64:443-51
Melamed, Michal L; Plantinga, Laura; Shafi, Tariq et al. (2013) Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators. BMC Nephrol 14:134

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