Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK059699-03
Application #
6524515
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Serrano, Jose
Project Start
2000-09-01
Project End
2005-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
3
Fiscal Year
2002
Total Cost
$227,588
Indirect Cost
Name
University of Florida
Department
Pathology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Santostefano, Katherine E; Hamazaki, Takashi; Pardo, Carolina E et al. (2012) Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors. J Biol Chem 287:30507-17
Brower, Jeffrey V; Lim, Chae Ho; Han, Chul et al. (2009) Differential CpG island methylation of murine adenine nucleotide translocase genes. Biochim Biophys Acta 1789:198-203
Kehoe, Sarah M; Oka, Masahiro; Hankowski, Katherine E et al. (2008) A conserved E2F6-binding element in murine meiosis-specific gene promoters. Biol Reprod 79:921-30
Brower, Jeffrey V; Rodic, Nemanja; Seki, Tsugio et al. (2007) Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis. J Biol Chem 282:29658-66
Singh, Amar M; Hamazaki, Takashi; Hankowski, Katherine E et al. (2007) A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells 25:2534-42
Oka, Masahiro; Rodic, Nemanja; Graddy, Jamie et al. (2006) CpG sites preferentially methylated by Dnmt3a in vivo. J Biol Chem 281:9901-8
Hamazaki, Takashi; Kehoe, Sarah M; Nakano, Toru et al. (2006) The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol Cell Biol 26:7539-49
Rodic, Nemanja; Oka, Masahiro; Hamazaki, Takashi et al. (2005) DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells. Stem Cells 23:1314-23
Hamazaki, Takashi; Oka, Masahiro; Yamanaka, Shinya et al. (2004) Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation. J Cell Sci 117:5681-6
Hamazaki, Takashi; Terada, Naohiro (2003) In vitro differentiation of embryonic stem cells into hepatocytes. Methods Enzymol 365:277-87

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