Rationale: Chromium supplementation has been postulated to have a beneficial effect in the management of diabetes, but routine use is not currently recommended due to the conflicting evidence regarding efficacy. Further, the cellular mechanisms by which chromium affects glucose homeostasis are currently unknown. Several lines of evidence, however, suggest that chromium may modulate intracellular pathways of glucose metabolism.Hypothesis: Our hypothesis is that, in subjects with Type 2 diabetes, chromium supplementation will improve whole-body, insulin-mediated glucose uptake by increasing non-oxidative glucose disposal (Aim 1). This increase will be due to changes in glucose transport and glycogen synthase activity at the myocellular level (Aim 2) and in cellular signaling through the insulin receptor regulating glucose uptake and glycogen synthase activity (Aim 3). Experimental Approach:. We will conduct a double-blinded, placebo-controlled intervention study in subjects with Type 2 diabetes. After assessment of baseline measures, subjects will be randomized to chromium or placebo for 24 weeks. We will then assess whole-body physiologic measures in addition to obtaining skeletal muscle biopsies for myocellular studies in situ. Significance: Chromium supplementation by the general public, and in people with diabetes in particular, has surpassed our ability as a scientific community to provide evidence regarding the safety and efficacy of its use. As such, randomized controlled trials with mechanistic aims are warranted and provide the rationale for this project. Therefore, the experiments proposed will provide new information regarding the effects of chromium on glucose homeostasis, and will provide the data necessary to generate recommendations for or against routine clinical use.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK060126-04
Application #
7098784
Study Section
Nutrition Study Section (NTN)
Program Officer
Staten, Myrlene A
Project Start
2003-09-30
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2008-07-31
Support Year
4
Fiscal Year
2006
Total Cost
$426,315
Indirect Cost
Name
Lsu Pennington Biomedical Research Center
Department
Type
Organized Research Units
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
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