Hepatitis C Virus NS5a Protein and Oxidative Stress

Siddiqui, Aleem

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK061566-02
• Application #: 6696347
• Study Section: General Medicine A Subcommittee 2 (GMA)
• Program Officer: Doo, Edward
• Project Start: 2003-01-08
• Project End: 2007-12-31
• Budget Start: 2004-01-01
• Budget End: 2004-12-31
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $324,653

Institution

• Name: University of Colorado Denver
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 041096314
• City: Aurora
• State: CO
• Country: United States
• Zip Code: 80045

Publications

Kim, Seong-Jun; Jang, Jae Young; Kim, Eun-Jung et al. (2017) Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation. Hepatology 66:758-771

Nasimuzzaman, Md; Waris, Gulam; Mikolon, David et al. (2007) Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol 81:10249-57

Waris, Gulam; Felmlee, Daniel Jeffery; Negro, Francesco et al. (2007) Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol 81:8122-30

Domitrovich, Angela M; Felmlee, Daniel J; Siddiqui, Aleem (2005) Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem 280:39802-8

Waris, Gulam; Siddiqui, Aleem (2005) Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J Virol 79:9725-34

Tardif, Keith D; Waris, Gulam; Siddiqui, Aleem (2005) Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 13:159-63

Waris, Gulam; Turkson, James; Hassanein, Tarek et al. (2005) Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol 79:1569-80

Domitrovich, Angela M; Diebel, Kevin W; Ali, Naushad et al. (2005) Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication. Virology 335:72-86

Tardif, Keith D; Mori, Kazutoshi; Kaufman, Randal J et al. (2004) Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem 279:17158-64

Waris, Gulam; Sarker, Shameema; Siddiqui, Aleem (2004) Two-step affinity purification of the hepatitis C virus ribonucleoprotein complex. RNA 10:321-9