The data structure and inferential goals for Health Services Research (HSR) and evaluation require use of a hierarchical model (HM) that accounts for the structure and specifies both population values and random effects for units such as clinics, physicians and health service regions. HMs properly account for the sample design and structure scientific and policy-relevant statistical inferences. Applications require valid and efficient estimation of population parameters (such as the average death rate), estimation of between unit variation (variance components) and inferences on unit-specific random effects. These include unit-specific ranks (to be used in profiling/league tables) estimates of the histogram of random unit-specific effects, estimation of how many and which unit-specific effects exceed a threshold, and identification of extremely poor and good performers. No single set of estimates can effectively address these multiple goals, and we will develop and evaluate a """"""""panel"""""""" of goal-specific summaries and inferences. The panel will combine efficiency (making good use of the available information) with robustness (high efficiency over a broad range of underlying assumptions).
Our specific aims are: structuring inferences via the Bayesian formalism; development, implementation, and application of robust priors; evaluation of the robustness, efficiency and operating characteristics of the panel of summaries; development and implementation of computational approaches, with focus on massive data sets; preparation of case studies based on Rand projects; hosting a summer intern at Rand. The proposed research will produce innovative statistical methodology and computer implementation, provide guidance on addressing multiple HSR goals, communicate interesting and informative case studies, educate and acculturate pre-doctoral students.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK061662-03S1
Application #
7231831
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Eggers, Paul Wayne
Project Start
2002-09-26
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2006
Total Cost
$43,948
Indirect Cost
Name
Johns Hopkins University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Schwender, Holger; Taub, Margaret A; Beaty, Terri H et al. (2012) Rapid testing of SNPs and gene-environment interactions in case-parent trio data based on exact analytic parameter estimation. Biometrics 68:766-73
Eckel, Sandrah P; Louis, Thomas A; Chaves, Paulo H M et al. (2012) Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study. Am J Epidemiol 176:214-23
Myers, Jessica A; Louis, Thomas A (2012) Comparing treatments via the propensity score: stratification or modeling? Health Serv Outcomes Res Methodol 12:29-43
Taub, Margaret A; Schwender, Holger; Beaty, Terri H et al. (2012) Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions. Genet Epidemiol 36:225-34
Eckel, Sandrah P; Bandeen-Roche, Karen; Chaves, Paulo H M et al. (2011) Surrogate screening models for the low physical activity criterion of frailty. Aging Clin Exp Res 23:209-16
Paddock, Susan M; Louis, Thomas A (2011) Percentile-based Empirical Distribution Function Estimates for Performance Evaluation of Healthcare Providers. J R Stat Soc Ser C Appl Stat 60:575-589
Paddock, Susan M; Hunter, Sarah B; Watkins, Katherine E et al. (2011) ANALYSIS OF ROLLING GROUP THERAPY DATA USING CONDITIONALLY AUTOREGRESSIVE PRIORS. Ann Appl Stat 5:605-627
An, Ming-Wen; Reich, Nicholas G; Crawford, Stephen O et al. (2011) A stochastic simulator of a blood product donation environment with demand spikes and supply shocks. PLoS One 6:e21752
Carvalho, Benilton S; Louis, Thomas A; Irizarry, Rafael A (2010) Quantifying uncertainty in genotype calls. Bioinformatics 26:242-9
Louis, Thomas A (2010) Discussion of ""conundrums with uncertainty factors"". Risk Anal 30:346-8; author reply 353

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