Diabetes is a major health care problem that has reached crisis proportions. The disease accounts for >14% of total national health care expenditures in the US, untold losses of precious human resources, and new therapies are urgently needed. We are developing a glucose sensor with telemetry for long-term (>1 year) implantation in subcutaneous tissues. In type 1 diabetes, the sensor would help avoid hyperglycemia, warn of hypoglycemia, direct insulin dosing, and provide the missing component of the artificial pancreas. In type 2 diabetes, the sensor would be useful for medication adjustment and reducing mean blood glucose. Blood glucose monitoring is central to all therapies for diabetes. Present monitoring methods rely on sampling by """"""""fingerstick"""""""" or recently introduced, short-term percutaneous needle-like senors. These methods are objectionable to most people with diabetes and are not suitable for children. Development by our group of a long-term implantable glucose sensor has been underway for many years. The unique and innovative sensor design based on differential glucose and oxygen detection overcomes limitations of sensor encapsulation by the body. Sensors implanted over 5 months in pigs remain responsive to glucose, although affected by the foreign body response. The sensor and telemetry implant system can serve as a unique experimental tool for the study of mass transfer in tissue surrounding implants, while determing the ability of the system to detect hypoglycemia. Multiple sensor-telemetry units will be implanted in non-diabetic and diabetic pigs for one year and glucose challenges will be performed. Tissue samples will be collected via biopsy for histologic analyses. Blood glucose recordings will be compared quantitatively with standard glucose assay. Mass transfer models will be constructed and predicted substrate fluxes will be compared with actual fluxes measured over the long term by implanted sensors.
| Lucisano, Joseph Y; Routh, Timothy L; Lin, Joe T et al. (2017) Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model. IEEE Trans Biomed Eng 64:1982-1993 |
| Wessling-Resnick, Marianne (2015) Nramp1 and Other Transporters Involved in Metal Withholding during Infection. J Biol Chem 290:18984-90 |
| Kumosa, Lucas S; Routh, Timothy L; Lin, Joe T et al. (2014) Permeability of subcutaneous tissues surrounding long-term implants to oxygen. Biomaterials 35:8287-96 |
| Gough, David A; Kumosa, Lucas S; Routh, Timothy L et al. (2010) Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med 2:42ra53 |
