Cdx2 modulates beta-catenin activity in intestinal cells

Lynch, John P.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 1R01DK068366-01A2
• Application #: 7046483
• Study Section: Gastrointestinal Cell and Molecular Biology Study Section (GCMB)
• Program Officer: Hamilton, Frank A
• Project Start: 2006-04-01
• Project End: 2010-12-31
• Budget Start: 2006-04-01
• Budget End: 2006-12-31
• Support Year: 1
• Fiscal Year: 2006
• Total Cost: $289,665

Institution

• Name: University of Pennsylvania
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Kong, Jianping; Crissey, Mary Ann S; Stairs, Douglas B et al. (2011) Cox2 and ?-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions. Neoplasia 13:792-805

Kong, Jianping; Crissey, Mary Ann; Funakoshi, Shinsuke et al. (2011) Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus. PLoS One 6:e18280

Crissey, Mary Ann S; Guo, Rong-Jun; Funakoshi, Shinsuke et al. (2011) Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology 140:517-528.e8

Verzi, Michael P; Hatzis, Pantelis; Sulahian, Rita et al. (2010) TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A 107:15157-62

Huo, Xiaofang; Zhang, Hui Ying; Zhang, X I et al. (2010) Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus. Gastroenterology 139:194-203.e1

Guo, Rong-Jun; Funakoshi, Shinsuke; Lee, Hannah H et al. (2010) The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis 31:159-66

Stairs, Douglas B; Kong, Jianping; Lynch, John P (2010) Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia. Prog Mol Biol Transl Sci 96:231-70

Funakoshi, Shinsuke; Kong, Jianping; Crissey, Mary Ann et al. (2010) Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. Am J Physiol Gastrointest Liver Physiol 299:G1054-67

Kong, Jianping; Stairs, Douglas B; Lynch, John P (2010) Modelling Barrett's oesophagus. Biochem Soc Trans 38:321-6

Kong, Jianping; Nakagawa, Hiroshi; Isariyawongse, Brandon K et al. (2009) Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis 30:122-30