This grant application is a longitudinal cohort study submitted in response to the NIH Request for Applications, RFA-HD-03-033, """"""""Establishing the Precursors of the Metabolic Syndrome in Children """""""". Our overall goal is to link the metabolic syndrome in adults [as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) to their childhood risk factors using long-term serial data collected from birth in 350 adult males and 348 adult females in the Fels Longitudinal Study. The ATP llI defines the metabolic syndrome in adults as having a cluster of three, four, or five risk factors that exceed criterion values, namely, waist circumference >102 cm for men and >88 cm for women;blood pressure >130/>85 mm Hg;plasma triglyceride level >150 mg/dL;plasma HDL-cholesterol level <40 mg/dL for men and <50mg/dL for women;and fasting plasma glucose >110 mg/dL. We propose (1) to determine if the onset of pathological values for any of the components of the metabolic syndrome begins in childhood;and, if so, to establish childhood criterion values for these biomarkers;(2) to examine in these 698 Fels adults changes and sexual dimorphism in values collected during their pubertal years for body fat, fat distribution, fat-free mass, lipid profiles, insulin resistance, blood pressure, leptin, adiponectin and C-reactive protein (CRP) in relation to the presence or absence of the metabolic syndrome in adulthood;and, (3) to relate adulthood changes in cardiac structure and hemodynamic parameters to contemporaneous changes in body fat, fat distribution, and fat-free mass and to metabolic syndrome over a three-year interval. We will conduct the proposed study using both the NCEP ATP III criterion of 110 mg/dL and the American Diabetes Association's (ADA) newly recommended criterion of 100 mg/dL for impaired fasting plasma glucose in order to elucidate the diagnostic implications of the lower threshold. Elucidating adverse relationships by linking childhood data to adult pathology may lead to the ability to detect children at elevated risk for the metabolic syndrome and, by implication, for type 2 diabetes mellitus and cardiovascular disease. The Fels long-term serial records provide a unique opportunity to accomplish our aims in an economical and efficient manner. Participants in the Fels Longitudinal Study are enrolled at birth and are not selected in regard to factors associated with any clinical condition. Consequently, the relationships revealed and the inferences drawn from the proposed study should reflect the natural history of the development of obesity, hypertension, dyslipidemia, and impaired glucose tolerance, and thus, should lead to the early identification of children at risk for the metabolic syndrome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK071485-06S1
Application #
7995023
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (33))
Program Officer
Linder, Barbara
Project Start
2010-01-01
Project End
2010-03-31
Budget Start
2010-01-01
Budget End
2010-03-31
Support Year
6
Fiscal Year
2010
Total Cost
$97,320
Indirect Cost
Name
Virginia Commonwealth University
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Lu, Juan; Shin, Yongyun; Yen, Miao-Shan et al. (2016) Peak Bone Mass and Patterns of Change in Total Bone Mineral Density and Bone Mineral Contents From Childhood Into Young Adulthood. J Clin Densitom 19:180-91
Sun, Shumei S; Sima, Adam P; Himes, John H (2014) Retarded tempo of physiological development in childhood delays the onset of the metabolic syndrome in adulthood. Ann Nutr Metab 65:175-83
Sun, S S; Sabo, Roy; Arslanian, S et al. (2012) Age variation and sexual dimorphism in the sixteen diagnostic clusters of risk factors for the metabolic syndrome. Z Gesundh Wiss 20:487-497
Sabo, Roy T; Lu, Zheng; Deng, Xiaoyan et al. (2012) Parental and offspring associations of the metabolic syndrome in the Fels Longitudinal Study. Am J Clin Nutr 96:461-6
Frank, L Matthew; Shinnar, Shlomo; Hesdorffer, Dale C et al. (2012) Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study. J Pediatr 161:1169-71
Chumlea, Wm C; Choh, A; Lee, M et al. (2012) MAINTAINING FUNCTION WITH AGING WHAT WE HAVE LEARNED FROM THE FELS LONGITUDINAL STUDY. J Frailty Aging 1:50-51
Wan, Wen; Deng, Xiaoyan; Archer, Kellie J et al. (2012) Pubertal pathways and the relationship to anthropometric changes in childhood: The Fels longitudinal study. Open J Pediatr 2:
Sun, Shumei S; Deng, Xiaoyan; Sabo, Roy et al. (2012) Secular trends in body composition for children and young adults: the Fels Longitudinal Study. Am J Hum Biol 24:506-14
Shinnar, Shlomo; Bello, Jacqueline A; Chan, Stephen et al. (2012) MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study. Neurology 79:871-7
Sabo, Roy T; Ren, Chungfeng; Sun, Shumei S (2012) Comparing Height-Adjusted Waist Circumference Indices: The Fels Longitudinal Study. Open J Endocr Metab Dis 2:40-48

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