Principal Investigator/Program Director (Last, first, middle): McDonnell, Donald P. RESEARCH &RELATED Other Project Information 1. * Are Human Subjects Involved? m Yes l No 1.a. If YES to Human Subjects Is the IRB review Pending? m Yes m No IRB Approval Date: Exemption Number: 1 2 3 4 5 6 Human Subject Assurance Number 2. * Are Vertebrate Animals Used? l Yes m No 2.a. If YES to Vertebrate Animals Is the IACUC review Pending? l Yes m No IACUC Approval Date: Animal Welfare Assurance Number A3195-01 3. * Is proprietary/privileged information m Yes l No included in the application? 4.a.* Does this project have an actual or potential impact on m Yes l No the environment? 4.b. If yes, please explain: 4.c. If this project has an actual or potential impact on the environment, has an exemption been authorized or an environmental assessment (EA) or environmental impact statement (EIS) been performed? m Yes m No 4.d. If yes, please explain: 5.a.* Does this project involve activities outside the U.S. or m Yes l No partnership with International Collaborators? 5.b. If yes, identify countries: 5.c. Optional Explanation: 6. * Project Summary/Abstract Abstract.pdf Mime Type: application/octet-stream 7. * Project Narrative ProjectNarrative.pdf Mime Type: application/octet-stream 8. Bibliography &References Cited Bibliography.pdf Mime Type: application/octet-stream 9. Facilities &Other Resources Facilities.pdf Mime Type: application/octet-stream 10. Equipment Tracking Number: Other Information Page 5 OMB Number: 4040-0001 Expiration Date: 04/30/2008 Principal Investigator/Program Director (Last, first, middle): McDonnell, Donald P. Abstract Because of their structural similarity to the canonical estrogen receptors (ER? and ER?), it has been considered that the estrogen receptor related (ERR) sub-family of orphan nuclear receptors function as regulators of estrogen responsiveness. It now appears, however, that activities unrelated to ER signaling are an equally important facet of ERR biology. Most notably, it has been shown that ERR? is a

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK074652-03S1
Application #
8012324
Study Section
Molecular and Cellular Endocrinology Study Section (MCE)
Program Officer
Margolis, Ronald N
Project Start
2010-02-04
Project End
2010-04-30
Budget Start
2010-02-04
Budget End
2010-04-30
Support Year
3
Fiscal Year
2010
Total Cost
$89,347
Indirect Cost
Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Chang, Ching-yi; McDonnell, Donald P (2012) Molecular pathways: the metabolic regulator estrogen-related receptor ýý as a therapeutic target in cancer. Clin Cancer Res 18:6089-95
Chang, Ching-yi; Kazmin, Dmitri; Jasper, Jeff S et al. (2011) The metabolic regulator ERRýý, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell 20:500-10
Alaynick, William A; Way, James M; Wilson, Stephanie A et al. (2010) ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol 24:299-309
Dwyer, Mary A; Joseph, James D; Wade, Hilary E et al. (2010) WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Res 70:9298-308
Stein, Rebecca A; Gaillard, Stéphanie; McDonnell, Donald P (2009) Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol 114:106-12
Grasfeder, Linda L; Gaillard, Stephanie; Hammes, Stephen R et al. (2009) Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol 23:1171-82
Stein, Rebecca A; Chang, Ching-Yi; Kazmin, Dmitri A et al. (2008) Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Res 68:8805-12
Hyatt, Stephen M; Lockamy, Elizabeth L; Stein, Rebecca A et al. (2007) On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. J Med Chem 50:6722-4