This proposal is submitted in response to RFA DK-03-022 """"""""Ancillary Studies to Obesity-Related Clinical Trials."""""""" We are making application to prospectively examine the cognitive effects of bariatric surgery in participants from the Longitudinal Assessment of Bariatric Surgery (LABS) project. There is growing evidence that obesity is associated with adverse neurocognitive outcome. Recent studies demonstrate that elevated body mass index (BMI) is an independent risk factor for Alzheimer's disease, structural brain abnormalities, and cognitive dysfunction in older adults. Preliminary work from our lab extends these findings and shows structural brain differences and cognitive dysfunction also exist in obese young and middle-aged adults. Bariatric surgery is increasingly viewed as an effective intervention for morbid obesity, though its effects on cognition are unknown. Post-operative nutritional deficiencies are common and can adversely impact cognitive performance. However, substantial weight loss resolves or improves many medical conditions with reversible cognitive effects, suggesting bariatric surgery may provide cognitive benefits. No study to date has examined the cognitive effects of bariatric surgery. To do so, the proposed study will prospectively assess cognitive performance in 125 bariatric surgery patients enrolled in the LABS project and 125 matched controls. Bariatric surgery patients will complete a computerized cognitive test battery at four time points: pre-operatively, 12weeks post-operatively, 12 months post-operatively, and 24 months post-operatively. Matched control participants will complete the test battery at similar intervals. Demographic, medical, and psychosocial information will be collected to elucidate possible mechanisms of change. We hypothesize that the substantial weight loss following bariatric surgery will be associated with improved cognitive performance. Findings from the proposed study will provide important information regarding: 1) the cognitive effects of bariatric surgery; 2) possible mechanisms for these effects; and 3) the contribution of cognitive performance to short- and long-term outcome of bariatric surgery. Determining these effects may impart key insight into the neurocognitive consequences of obesity and identify the most effective treatment options.
| Sanborn, Victoria E; Spitznagel, Mary-Beth; Crosby, Ross et al. (2018) Cognitive function and quality of life in bariatric surgery candidates. Surg Obes Relat Dis 14:1396-1401 |
| Spitznagel, Mary Beth; Alosco, Michael; Inge, Thomas H et al. (2016) Adolescent weight history and adult cognition: before and after bariatric surgery. Surg Obes Relat Dis 12:1057-64 |
| Alosco, Michael L; Brickman, Adam M; Spitznagel, Mary Beth et al. (2016) Reduced Gray Matter Volume Is Associated With Poorer Instrumental Activities of Daily Living Performance in Heart Failure. J Cardiovasc Nurs 31:31-41 |
| Alosco, Michael L; Brickman, Adam M; Spitznagel, Mary Beth et al. (2015) Daily Physical Activity Is Associated with Subcortical Brain Volume and Cognition in Heart Failure. J Int Neuropsychol Soc 21:851-60 |
| Alosco, Michael L; Spitznagel, Mary Beth; Strain, Gladys et al. (2015) Pre-operative history of depression and cognitive changes in bariatric surgery patients. Psychol Health Med 20:802-13 |
| Alosco, Michael L; Spitznagel, Mary Beth; Sweet, Lawrence H et al. (2015) Cognitive dysfunction mediates the effects of poor physical fitness on decreased functional independence in heart failure. Geriatr Gerontol Int 15:174-81 |
| Alosco, Michael L; Spitznagel, Mary Beth; Cohen, Ronald et al. (2015) Obesity and cognitive dysfunction in heart failure: the role of hypertension, type 2 diabetes, and physical fitness. Eur J Cardiovasc Nurs 14:334-41 |
| Alosco, Michael L; Spitznagel, Mary Beth; Josephson, Richard et al. (2015) COPD is associated with cognitive dysfunction and poor physical fitness in heart failure. Heart Lung 44:21-6 |
| Manderino, L; Spitznagel, M B; Strain, G et al. (2015) Cognitive dysfunction predicts poorer emotion recognition in bariatric surgery candidates. Obes Sci Pract 1:97-103 |
| Alosco, Michael L; Spitznagel, Mary Beth; Strain, Gladys et al. (2015) Improved serum leptin and ghrelin following bariatric surgery predict better postoperative cognitive function. J Clin Neurol 11:48-56 |
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