Kidney transplant (KTx) professionals have many choices of immunosuppressive (IS) medications and regimens for their patients. With early acute rejection (AR) rates now low and short term graft survival high, individualized long-term graft survival depends on patients'underlying co-morbidities or complications of IS medications. Yet few studies or data exist on how to balance the trade-offs between IS efficacy (in preventing AR) versus complications, including infections, cancers and new onset diabetes after transplant (NODAT). Randomized trials or FDA-sanctioned Risk Evaluation and Mitigation Strategies help with very specific situations;but along with prior analyses of large national databases, also have many limitations. In this study, we propose to use a novel, three-database linkage of the a) U.S.A. national Organ Procurement and Transplant Network (OPTN) registry: recording initial data on all KTx and subsequent survival outcomes, b) a Medicare billing claims database: covers the first 3 years post-KTx, and c) a national Pharmacy Clearinghouse Database (PCD) that covers 60% of all medication fills in the U.S.A. Using this integration, we can minimize limitations of prior approaches to develop accurate, longitudinal, national level data on the transplant procedures, IS use, survival and non-fatal morbidity. Our investigative team of KTx specialists, economists and statisticians, all with transplant database and outcomes research expertise, can then assess in a more rigorous way than previously possible, the efficacy and morbidity tradeoffs of the IS regimens and doses. In the proposed CISTEM study (Choosing Immune Suppression in Renal Transplantation by Efficacy and Morbidity), we will complete the following three aims: 1) To construct a novel linkage of data from the OPTN registry, an updated Medicare claims dataset and the PCD to quantify the associations of KTx IS with outcome metrics of efficacy and morbidity, adjusted for demographic, medical and immunologic parameters;through propensity-score and covariate-adjusted survival models that will quantify the association between IS regimen or dose and specific measures of efficacy (AR) or morbidity (major infections, cancers, NODAT) that contribute to the hard outcomes of graft survival and patient survival, with sub-analyses for key racial and high-risk subgroups;2) To use the transition probabilities of events, generated in aim 1, to develop Markov models and calculate the overall cost-effectiveness, including trade-off costs, for each of the major IS regimens in use, by overall group and in the key sub-groups mentioned above;and 3) To use the decision analytics from Aims 1 and 2 to generate individualized and real-time reports of the predicted efficacy/complications outcomes and costs of different KTx IS regimens through a free and updateable patient-focused web- or mobile phone-based risk engine and communication tool. The long-term significance is that physicians and patients will be able to make IS choices in a more cost-effective and better informed manner than any other strategy currently available.
Kidney transplantation is an expensive treatment for end-stage kidney failure, but less expensive over the long-term than dialysis or a return to dialysis i the transplant fails. Therefore, maintaining the longest transplant and patient survival is highly desirable, but depends now on a balance between immunosuppressive medication efficacy and morbidity. This project will quantify the adjusted risks and additional costs for key efficacy and morbidity events with many commonly used immunosuppressive medications regimens and doses, then use the medical and cost data to develop a web- and mobile-phone based tool for individualized predictions that physicians and patients can use to make more informed decisions.
|Lentine, Krista L; Naik, Abhijit S; Ouseph, Rosemary et al. (2018) Antidepressant medication use before and after kidney transplant: implications for outcomes - a retrospective study. Transpl Int 31:20-31|
|Lentine, K L; Lam, N N; Naik, A S et al. (2018) Prescription opioid use before and after kidney transplant: Implications for posttransplant outcomes. Am J Transplant 18:2987-2999|
|Dharnidharka, Vikas R; Naik, Abhijit S; Axelrod, David A et al. (2018) Center practice drives variation in choice of US kidney transplant induction therapy: a retrospective analysis of contemporary practice. Transpl Int 31:198-211|
|Nazzal, Mustafa; Gadani, Sameer; Said, Abdullah et al. (2018) Liver targeted therapies for hepatocellular carcinoma prior to transplant: contemporary management strategies. Glob Surg 4:|
|Lam, Ngan N; Lentine, Krista L; Klarenbach, Scott et al. (2018) Validation of Living Donor Nephrectomy Codes. Can J Kidney Health Dis 5:2054358118760833|
|Haugen, Christine E; Mountford, Alexandra; Warsame, Fatima et al. (2018) Incidence, Risk Factors, and Sequelae of Post-kidney Transplant Delirium. J Am Soc Nephrol 29:1752-1759|
|Vest, L S; Koraishy, F M; Zhang, Z et al. (2018) Metformin use in the first year after kidney transplant, correlates, and associated outcomes in diabetic transplant recipients: A retrospective analysis of integrated registry and pharmacy claims data. Clin Transplant 32:e13302|
|Axelrod, D A; Schnitzler, M A; Alhamad, T et al. (2018) The impact of direct-acting antiviral agents on liver and kidney transplant costs and outcomes. Am J Transplant 18:2473-2482|
|Choudhry, Swati; Dharnidharka, Vikas R; Castleberry, Chesney D et al. (2017) End-stage renal disease after pediatric heart transplantation: A 25-year national cohort study. J Heart Lung Transplant :|
|Dharnidharka, Vikas R; Naik, Abhijit S; Axelrod, David et al. (2017) Clinical and Economic Consequences of Early Cancer After Kidney Transplantation in Contemporary Practice. Transplantation 101:858-866|
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