The adolescent brain is driven to seek out novel reinforcers, but the areas of the brain involved in impulse control and executive function remain immature until early adulthood. This may make adolescents particularly susceptible to overeating and weight gain. Motivation to eat, or reinforcing value, is a strong predictor of energy consumption and adiposity. Understanding factors that lead to higher levels of the reinforcing value of food is a critical first step toward developing novel treatment and prevention strategies for obesity. Our previous work has shown that repeated intake of snack foods, such as potato chips and chocolate candy, decreases the reinforcing value of that snack food in non-obese adults, but increases the reinforcing value of that snack food in a subset of obese adults. To date, this relationship has been demonstrated in cross-sectional studies. In addition, our preliminary data, presented in this application, suggest that individuals who increase responses for healthier snack foods (energy density <1.5 kcal/gram) weigh less than those who decrease responses for these foods after repeated administration. This suggests that sensitization of the reinforcing value of food may be a risk or a protective factor against obesity depending on the type of food being consumed. Another protective factor may be having a high reinforcing value of physical activity. Studies have shown that individuals who find physical activity very reinforcing weigh less. Finally, our work and that of others suggests that individuals who are high in reinforcing value of food and high in delay discounting may be at greater risk for weight gain. The purpose of the proposed study is to 1) determine if increases in the reinforcing value of high energy density snack foods predict weight gain over time. 2) Determine if increases in the reinforcing value of low energy density snacks protects against weight gain over time 3) to determine if reinforcing value of physical activity and/or delay discounting moderate the relationship between sensitization of the reinforcing value of food on weight change in adolescents. These studies will allow us not only to determine the weight-related consequences of sensitization of the reinforcing value of food, but also to identify factors that moderate changes in body weight over time as they relate to the reinforcing value of food. Once these factors are identified and characterized, future studies could focus on refining methods for altering the reinforcing value of food as a way to increase healthy eating and decrease less healthy food intake.

Public Health Relevance

Understanding factors that impact motivation to eat is critical to preventing weight gain and obesity. Our previous work has shown that some obese individuals increase motivation to get snack food after repeated intake, which reduces motivation to eat in non-obese adults. The proposed studies will determine if this pattern of responding for food predicts weight gain over time in adolescents, if adolescents who show this same pattern after eating healthier foods are protected from weight gain, and the role that physical activity and delay discounting play in moderating these interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK106265-02
Application #
9222747
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Osganian, Voula
Project Start
2016-03-01
Project End
2021-02-28
Budget Start
2017-03-01
Budget End
2018-02-28
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Other Health Professions
Type
Sch Allied Health Professions
DUNS #
038633251
City
Amherst
State
NY
Country
United States
Zip Code
14228
Temple, Jennifer L; Van der Kloet, Erika; Atkins, Amanda M et al. (2017) Daily exposure to either a high- or low-energy-dense snack food reduces its reinforcing value in adolescents. Obesity (Silver Spring) 25:432-437
Temple, Jennifer L; Bernard, Christophe; Lipshultz, Steven E et al. (2017) The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry 8:80