Recent studies have clearly indicated that a significant proportion of bariatric surgery patients experience substantial weight regain and struggle with depression following their surgery. Understanding the mechanisms that contribute to these negative clinical outcomes is of considerable scientific and clinical importance. In the present study, we propose a model of predictors that we believe result in weight regain and depression. We will test the idea that in the moment, stress and negative affect predict loss of control eating, and that over time, loss of control eating predicts weight regain and depression in these patients. We will also investigate the influence of disinhibition on these relationships. Furthermore, we will use contemporary ecological momentary assessment and ambulatory assessment techniques to measure these variables and study their relationship to weight regain and depression in a prospective, longitudinal design. Finally, we will longitudinally examine weight regain and depression following bariatric surgery to clarify the temporal relationship between these variables.

Public Health Relevance

The proposed project will examine a variety of predictors of depression and weight regain in participants who have undergone bariatric surgery. Furthermore, this study will attempt to clarify the theoretically reciprocal relationship between weight regain and depression in bariatric surgery patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK112487-05
Application #
10000130
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Unalp-Arida, Aynur
Project Start
2016-09-15
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Sanford Research North
Department
Type
DUNS #
068157924
City
Fargo
State
ND
Country
United States
Zip Code
58103
Bond, Dale S; Thomas, J Graham; Lipton, Richard B et al. (2018) Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial. Obesity (Silver Spring) 26:81-87