Modulation of the Intercellular Junction Cadherins

Siahaan, Teruna J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Biomedical Imaging and Bioengineering (NIBIB)
• Type: Research Project (R01)
• Project #: 5R01EB000226-04
• Application #: 6750054
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Program Officer: Moy, Peter
• Project Start: 2001-07-01
• Project End: 2006-06-30
• Budget Start: 2004-07-01
• Budget End: 2006-06-30
• Support Year: 4
• Fiscal Year: 2004
• Total Cost: $229,163

Institution

• Name: University of Kansas Lawrence
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 076248616
• City: Lawrence
• State: KS
• Country: United States
• Zip Code: 66045

Publications

Kiptoo, Paul; Sinaga, Ernawati; Calcagno, Anna M et al. (2011) Enhancement of drug absorption through the blood-brain barrier and inhibition of intercellular tight junction resealing by E-cadherin peptides. Mol Pharm 8:239-49

Zheng, Kai; Laurence, Jennifer S; Kuczera, Krzysztof et al. (2009) Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chem Biol Drug Des 73:584-98

Zheng, Kai; Middaugh, C Russell; Siahaan, Teruna J (2009) Evaluation of the physical stability of the EC5 domain of E-cadherin: effects of pH, temperature, ionic strength, and disulfide bonds. J Pharm Sci 98:63-73

Trivedi, Maulik V; Laurence, Jennifer S; Siahaan, Teruna J (2009) The role of thiols and disulfides on protein stability. Curr Protein Pept Sci 10:614-25

Trivedi, Maulik; Davis, R Andrew; Shabaik, Yumna et al. (2009) The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin. J Pharm Sci 98:3562-74

Dunehoo, Alison L; Anderson, Meagan; Majumdar, Sumit et al. (2006) Cell adhesion molecules for targeted drug delivery. J Pharm Sci 95:1856-72

Zheng, Kai; Trivedi, Maulik; Siahaan, Teruna J (2006) Structure and function of the intercellular junctions: barrier of paracellular drug delivery. Curr Pharm Des 12:2813-24

Calcagno, Anna Maria; Fostel, Jennifer M; Orchekowski, Randal P et al. (2005) Modulation of cell adhesion molecules in various epithelial cell lines after treatment with PP2. Mol Pharm 2:170-84

Huang, Meng; Matthews, Kametra; Siahaan, Teruna J et al. (2005) Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium. Am J Physiol Gastrointest Liver Physiol 288:G67-73

Anderson, Meagan E; Yakovleva, Tatyana; Hu, Yongbo et al. (2004) Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides. Bioorg Med Chem Lett 14:1399-402