One unique feature of SPECT is the ability to use two pharmaceuticals labeled with different isotopes emitting photons with different energies to make simultaneous measurements of different physiological processes. Simultaneous acquisition of projection data from two isotopes has the advantage that it allows measurement of two potentially related processes (e.g., rest and stress perfusion or perfusion and receptor density) at the same time. This may add additional diagnostic information and, in addition, there are practical advantages such as increased patient throughput, elimination of problems with registration and results in common patient motion in the two studies. However, due to scatter in the patient and gamma camera and the poor energy resolution of conventional gamma cameras, dual isotope acquisition will result in cross talk contamination of the two sets of projection data. In this work we hypothesize that we can develop methods for simultaneously acquiring and reconstructing dual isotope images that can reduce the effects of this cross talk to the point where the images have diagnostic image quality close to that which they would have if acquired separately. We have chosen to focus on two specific applications: dual isotope Tc-99m/ TI-201 stress/rest myocardial perfusion SPECT and dual isotope Tc-99m/I-123 brain SPECT, with major emphasis on Tc-99m/TI-201 imaging. Toward this end we propose to: (1) Develop methods for optimizing and evaluating simultaneous TI-201/Tc-99m imaging (2) Develop and implement improved cross talk compensation methods for simultaneous dual isotope SPECT (3) Develop optimized acquisition methods for Tc-99m/TI-201 myocardial perfusion SPECT; (4) To evaluate these methods using simulated data and mathematical observers; (5) To evaluate simultaneous dual isotope Tc-99m/I-123 SPECT using phantom experiments and quantitative measures of image quality; and (6) To perform a clinical evaluation of simultaneous and separate acquisition of dual isotope rest/stress myocardial perfusion SPECT. Given the frequency with which this procedure is performed and the significant improvement in both patient comfort and clinical throughput, we believe this would have a substantial impact on clinical practice. We also will have developed techniques for simultaneous Tc-99m/I-123 brain imaging that may prove important as new I-123 and Tc-99m labeled brain agents are developed and marketed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
2R01EB000288-06
Application #
6579097
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Sastre, Antonio
Project Start
1999-02-01
Project End
2008-01-31
Budget Start
2003-02-05
Budget End
2004-01-31
Support Year
6
Fiscal Year
2003
Total Cost
$352,635
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Li, Xin; Jha, Abhinav K; Ghaly, Michael et al. (2017) Use of Sub-Ensembles and Multi-Template Observers to Evaluate Detection Task Performance for Data That are Not Multivariate Normal. IEEE Trans Med Imaging 36:917-929
Ghaly, Michael; Links, Jonathan M; Frey, Eric (2015) Optimization of energy window and evaluation of scatter compensation methods in myocardial perfusion SPECT using the ideal observer with and without model mismatch and an anthropomorphic model observer. J Med Imaging (Bellingham) 2:
Ghaly, Michael; Links, Jonathan M; Frey, Eric C (2015) Optimization and comparison of simultaneous and separate acquisition protocols for dual isotope myocardial perfusion SPECT. Phys Med Biol 60:5083-101
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He, Xin; Cheng, Lishui; Fessler, Jeffrey A et al. (2011) Regularized image reconstruction algorithms for dual-isotope myocardial perfusion SPECT (MPS) imaging using a cross-tracer prior. IEEE Trans Med Imaging 30:1169-83
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He, Xin; Gallas, Brandon D; Frey, Eric C (2010) Three-class ROC analysis--toward a general decision theoretic solution. IEEE Trans Med Imaging 29:206-15
He, Bin; Frey, Eric C (2010) The impact of 3D volume of interest definition on accuracy and precision of activity estimation in quantitative SPECT and planar processing methods. Phys Med Biol 55:3535-44

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