The long-term goal of this project is to develop quantitative imaging task based metrics and, using them, determine the fundamental limits on quantitative SPECT. In the previous project period, we focused on optimization of methods to correct for scatter, attenuation, and distance- dependent spatial resolution, as well as optimizing the acquisition strategy for imaging deep brain structures. In this renewal application, we turn our attention to the areas of simultaneous dual-isotope imaging, comparison of analytical and iterative image processing and reconstruction and on generalizing collimation advances, developed during the last project period for a dedicated brain system, to more commonly available dual-head systems. Our approaches include analysis, simulation, phantom experiments and patient studies. The analyses and simulation studies, although pertaining to prototypical estimation and classification tasks, will incorporate realistic anatomy and biological variability. We will continue the development of special-purpose collimators which sample the projections unequally in order to compensate for loss of information from central brain structures by attenuation. We will manufacture one such collimator, designed for a dedicated brain SPECT system during the last project period. We will design a similar collimator for a dual-head SPECT system, optimizing its performance for quantitative brain imaging tasks, relevant to Parkinson disease, using computer simulations of an anatomically realistic digital phantom. We will also determine the theoretical limits on activity estimation in simultaneous dual-energy imaging for both Tc/I and Tc/TI, and assess the value of dual-isotope imaging in clinical tasks related to glioblastoma and adult attention deficit hyperactivity disorder. We will compare analytical methods to correct for attenuation and distance dependent resolution to corrections incorporated into an iterative reconstruction algorithm in prototypical estimation tasks, as well as clinical tasks relevant to Alzheimer disease.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Project (R01)
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Special Emphasis Panel (ZRG1-SRB (33))
Program Officer
Haller, John W
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Brigham and Women's Hospital
United States
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Park, Mi-Ae; Kijewski, Marie Foley; Keijzers, Ronnie et al. (2016) Introduction of a novel ultrahigh sensitivity collimator for brain SPECT imaging. Med Phys 43:4734
Sitek, Arkadiusz; Moore, Stephen C (2013) Evaluation of imaging systems using the posterior variance of emission counts. IEEE Trans Med Imaging 32:1829-39
Park, Mi-Ae; Moore, Stephen C; Müller, Stefan P et al. (2013) Performance of a high-sensitivity dedicated cardiac SPECT scanner for striatal uptake quantification in the brain based on analysis of projection data. Med Phys 40:042504
Sitek, Arkadiusz (2012) Data analysis in emission tomography using emission-count posteriors. Phys Med Biol 57:6779-95
Moore, Stephen C; Southekal, Sudeepti; Park, Mi-Ae et al. (2012) Improved regional activity quantitation in nuclear medicine using a new approach to correct for tissue partial volume and spillover effects. IEEE Trans Med Imaging 31:405-16
Southekal, Sudeepti; McQuaid, Sarah J; Kijewski, Marie Foley et al. (2012) Evaluation of a method for projection-based tissue-activity estimation within small volumes of interest. Phys Med Biol 57:685-701
McQuaid, Sarah J; Southekal, Sudeepti; Kijewski, Marie Foley et al. (2011) Joint optimization of collimator and reconstruction parameters in SPECT imaging for lesion quantification. Phys Med Biol 56:6983-7000
Sitek, Arkadiusz (2011) Reconstruction of emission tomography data using origin ensembles. IEEE Trans Med Imaging 30:946-56
Park, Mi-Ae; Zimmerman, Robert E; Taberner, Andrew et al. (2008) Design and fabrication of phantoms using stereolithography for small-animal imaging systems. Mol Imaging Biol 10:231-6
Ouyang, Jinsong; El Fakhri, Georges; Moore, Stephen C (2008) Improved activity estimation with MC-JOSEM versus TEW-JOSEM in 111In SPECT. Med Phys 35:2029-40

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