The goal of this proposal is two-fold: (1) to further develop and validate a technology, magnetic resonance elastography (MRE), for quantitatively imaging mechanical properties and tension distribution in muscle and (2) to apply the technique for in vivo evaluation of patients with four common, and clinically significant muscle disorders (spasticity, disuse atrophy, myofascial pain and a metabolic myopathy). These studies will employ a magnetic resonance imaging sequence with synchronous motion-sensitizing gradients to map propagating shear waves in the muscle. The technique will assess the mechanical properties of the muscle and its tension distribution. Specifically, the study can be divided into three specific aims.
Aim 1 : Optimize MRE methods of acquisition and analysis for the assessment of muscle, including electromechanical drivers, data acquisition techniques, and methods for image analysis. Advanced techniques for very rapid MRE assessment of muscle will continue to be developed.
Aim 2 : Validate the MRE assessment of muscle properties and tension with phantom, ex-vivo muscle, and Finite Element Modeling (FEM) techniques. Finite Element Analysis will be performed by using both phantom and bovine muscles to better correlate MRE wave-length findings as function of muscle properties, tension and fiber architecture.
Aim 3 : Study In Vivo Normal and Abnormal Muscle. The MRE technique will be applied in vivo to provide elastographic images of abnormal muscle with known disorders. The patient groups chosen for study are each important in their own right, and furnish unique information across the spectrum of muscular disease and dysfunction. Groups to be studied include individuals with new onset of spasticity following an ischemic, hemispheric stroke, disuse atrophy as a result of immobilization, metabolic (hyperthyroid) myopathy and myofascial pain for trigger point identification. The overall hypothesis of this work is that will bring benefits to both basic research and clinical care. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000812-07
Application #
7035340
Study Section
Special Emphasis Panel (ZRG1-SMB (01))
Program Officer
Mclaughlin, Alan Charles
Project Start
1999-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
7
Fiscal Year
2006
Total Cost
$356,423
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
McCullough, Matthew B; Domire, Zachary J; Reed, Ann M et al. (2011) Evaluation of muscles affected by myositis using magnetic resonance elastography. Muscle Nerve 43:585-90
Rowe, Justin; Chen, Qingshan; Domire, Zachary J et al. (2010) Effect of collagen digestion on the passive elastic properties of diaphragm muscle in rat. Med Eng Phys 32:90-4
Muraki, Takayuki; Domire, Zachary J; McCullough, Matthew B et al. (2010) Measurement of stiffness changes in immobilized muscle using magnetic resonance elastography. Clin Biomech (Bristol, Avon) 25:499-503
Domire, Zachary J; McCullough, Matthew B; Chen, Qingshan et al. (2009) Wave attenuation as a measure of muscle quality as measured by magnetic resonance elastography: initial results. J Biomech 42:537-40
Domire, Zachary J; McCullough, Matthew B; Chen, Qingshan et al. (2009) Feasibility of using magnetic resonance elastography to study the effect of aging on shear modulus of skeletal muscle. J Appl Biomech 25:93-7
Ehman, E C; Rossman, P J; Kruse, S A et al. (2008) Vibration safety limits for magnetic resonance elastography. Phys Med Biol 53:925-35
Chen, Qingshan; Basford, Jeffrey; An, Kai-Nan (2008) Ability of magnetic resonance elastography to assess taut bands. Clin Biomech (Bristol, Avon) 23:623-9
Bensamoun, Sabine F; Glaser, Kevin J; Ringleb, Stacie I et al. (2008) Rapid magnetic resonance elastography of muscle using one-dimensional projection. J Magn Reson Imaging 27:1083-8
Chen, Qingshan; Bensamoun, Sabine; Basford, Jeffrey R et al. (2007) Identification and quantification of myofascial taut bands with magnetic resonance elastography. Arch Phys Med Rehabil 88:1658-61
Bensamoun, Sabine F; Ringleb, Stacie I; Chen, Qingshan et al. (2007) Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. J Magn Reson Imaging 26:708-13

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