The overall goal of this project is to develop and optimize a magnetic resonance imaging (MRI) technique for novel quantitative measurements of the macromolecular content and dynamics in tissues with special relevance to the characterization of brain myelin. The applicant has demonstrated in previous work that a novel MRI technique can be used to quantify (he ralio of the sizes of macromolecular and free water proton pools in biological systems, and provide a quantitative measure of the magnetization transfer (MT) rate constant between these different tissue subcomponents. The proposed studies will further develop and optimize this technique, will compare this technique to other MT techniques, and vll use the optimum technique in combination with multi-component T2 measurements to investigate the changes in water cempartmeritation and exchange rates that occur in white matter and demyelinated lesions.
The specific aims of the project are as follows: * to further develop selective inversion recovery (SIR) and to optimize both SIR and the pulsed saturation technique for speed, reliability, and accuracy for quantitatively measuring novel tissue properties. * to compare SIR to pulsed saturation and to validate both these methods against a known standard in a series of measurements on model biopolymers. * to evaluate optimized methods of quantitative MT imaging in biopolymers and in vivo in healthy rats. * to evaluate the sensitivity of quantitative MT imaging to changes in brain matter due to demyelination, inflamation, and axonal loss as revealed by histology, producing information that will further develop applications of MRI in multiple sclerosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB001452-01A2
Application #
6972967
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Mclaughlin, Alan Charles
Project Start
2005-07-12
Project End
2009-04-30
Budget Start
2005-07-12
Budget End
2006-04-30
Support Year
1
Fiscal Year
2005
Total Cost
$341,626
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Gore, John C; Zu, Zhongliang; Wang, Ping et al. (2017) ""Molecular"" MR imaging at high fields. Magn Reson Imaging 38:95-100
Janve, Vaibhav A; Zu, Zhongliang; Yao, Song-Yi et al. (2013) The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions. Neuroimage 74:298-305
Quarles, C Chad; Gore, John C; Xu, Lei et al. (2012) Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters. Magn Reson Imaging 30:944-53
Horch, R Adam; Gochberg, Daniel F; Nyman, Jeffry S et al. (2011) Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray. PLoS One 6:e16359
Zu, Zhongliang; Li, Ke; Janve, Vaibhav A et al. (2011) Optimizing pulsed-chemical exchange saturation transfer imaging sequences. Magn Reson Med 66:1100-8
Dortch, Richard D; Li, Ke; Gochberg, Daniel F et al. (2011) Quantitative magnetization transfer imaging in human brain at 3 T via selective inversion recovery. Magn Reson Med 66:1346-52
Dula, Adrienne N; Gochberg, Daniel F; Valentine, Holly L et al. (2010) Multiexponential T2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord. Magn Reson Med 63:902-9
Li, Ke; Zu, Zhongliang; Xu, Junzhong et al. (2010) Optimized inversion recovery sequences for quantitative T1 and magnetization transfer imaging. Magn Reson Med 64:491-500
Horch, R Adam; Wilkens, Ken; Gochberg, Daniel F et al. (2010) RF coil considerations for short-T2 MRI. Magn Reson Med 64:1652-7
Quarles, C C; Gochberg, D F; Gore, J C et al. (2009) A theoretical framework to model DSC-MRI data acquired in the presence of contrast agent extravasation. Phys Med Biol 54:5749-66

Showing the most recent 10 out of 17 publications