The objective of this proposal is to explore the development of a detector capable of detecting with high sensitivity and high spatial resolution optical photons in the visible wavelength as well as high energy photons, such as those emitted during positron annihilation. We further propose to use this new detector to construct a prototype imaging system that will be capable to non-invasively and repeatedly image small animal models in-vivo for the presence of either Positron Emission Tomography (PET) or optical signals. We will call this new device optical PET (OPET). Our interest is in ultimately using this technology as a tool that will enable translational research by bridging optical imaging at the cellular and small animal level, to microPET and on to human PET applications in the clinic. While we develop this technology for this translational research application, we expect that a multitude of other applications will manifest themselves from the photon counting nature of operation and high sensitivity of this device. We have previously developed the second generation of the high-resolution microPET scanners, and we plan to use a similar detector configuration for the detection of both optical and PET signals. This novel device therefore will use the same physical detector, and will completely eliminate the need for software image registration between PET and optical images. Specifically in this proposal, we plan to investigate different position sensitive and multi-channel imaging photodetectors, ranging from multi-channel photomultiplier tubes with different photocathode materials, to silicone based Avalanche Photo Diode (APD) detectors. We will also study methods of optimizing and maximizing the collection of light photons from scintillation events as well as optical signals. Finally we will build a prototype system based on a small number of detectors, and we will acquire the initial optical/PET studies. The developed imaging system will be a new tool dedicated to imaging small animals and will have high sensitivity and spatial resolution for both signals. We expect it to have optical signal sensitivity equivalent to state of the art optical imaging systems, PET absolute system sensitivity of state of the art commercial systems (on the order of 2%), and spatial resolution on the order of 2 mm. Furthermore, this imaging system will be of reduced cost, due to its field of view customized to the application of small animal imaging.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB001458-03
Application #
7006679
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Anderson, John F
Project Start
2004-03-17
Project End
2007-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$329,946
Indirect Cost
Name
University of California Los Angeles
Department
Pharmacology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Gu, Z; Prout, D L; Silverman, R W et al. (2015) A DOI Detector With Crystal Scatter Identification Capability for High Sensitivity and High Spatial Resolution PET Imaging. IEEE Trans Nucl Sci 62:740-747
Lu, Yujie; Machado, Hidevaldo B; Bao, Qinan et al. (2011) In vivo mouse bioluminescence tomography with radionuclide-based imaging validation. Mol Imaging Biol 13:53-8
Cong, Alexander; Cong, Wenxiang; Lu, Yujie et al. (2010) Differential evolution approach for regularized bioluminescence tomography. IEEE Trans Biomed Eng 57:2229-38
Lu, Yujie; Machado, Hidevaldo B; Douraghy, Ali et al. (2009) Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework. Opt Express 17:16681-95
Lu, Yujie; Chatziioannou, Arion F (2009) A Parallel Adaptive Finite Element Method for the Simulation of Photon Migration with the Radiative-Transfer-Based Model. Commun Numer Methods Eng 25:751-770
Lu, Yujie; Douraghy, Ali; Machado, Hidevaldo B et al. (2009) Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation. Phys Med Biol 54:6477-93
Cong, A; Cong, W; Shen, H et al. (2009) OPTICAL PROPERTY CHARACTERIZATION BASED ON A PHASE FUNCTION APPROXIMATION MODEL. Proc IEEE Int Symp Biomed Imaging :446-449
Lu, Yujie; Zhang, Xiaoqun; Douraghy, Ali et al. (2009) Source reconstruction for spectrally-resolved bioluminescence tomography with sparse a priori information. Opt Express 17:8062-80
Alexandrakis, George; Rannou, Fernando R; Chatziioannou, Arion F (2006) Effect of optical property estimation accuracy on tomographic bioluminescence imaging: simulation of a combined optical-PET (OPET) system. Phys Med Biol 51:2045-53
Alexandrakis, George; Rannou, Fernando R; Chatziioannou, Arion F (2005) Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study. Phys Med Biol 50:4225-41

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