? Though widely used for functional neuroimaging, BOLD fMRI measures a relative change in blood oxygenation and is subject to confounds due to variations in baseline physiology and the competing effects of changes in blood flow and oxygen metabolism. These uncertainties currently limit BOLD imaging and have stymied applications that depend on repeatability. An attractive strategy for working around these BOLD limitations is to pursue a quantitative measure of the relative change in the cerebral metabolic rate of oxygen (rCMRO2) synthesized from a complete set of hemodynamic parameters, fMRI, by itself, is currently unable to provide this complete set of hemodynamic parameters in humans during brain activation without relying on untested assumptions relating flow and volume changes. The goal of this grant is to develop and validate a multi-modality methodology for metabolic neuroimaging of the cortex through the integration of Diffuse Optical Tomography (DOT) and MRI. In this project, we will advance DOT technology to increase the quantitative accuracy of estimated baseline and dynamic hemoglobin concentrations. A novel hybrid time domain and continuous wave brain imaging system will be combined with MRI guided reconstruction methods. The quantitative baseline and functional optical measures of total hemoglobin, and deoxyhemoglobin will be combined with fMRI arterial spin labeling measures of the relative change in cerebral blood flow (rCBF) to calculate images of rCMRO2. Validation will be pursued through a combination of graded global and focal modulations and through comparison with analogous fMRI measures. We anticipate that validation of this metabolic imaging method will have wide applications both in studies of metabolic-vascular response in normal and diseased humans and use as a quantitative functional neuroimaging method to facilitate future longitudinal and across subject studies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB002482-01
Application #
6729464
Study Section
Special Emphasis Panel (ZRG1-SRB (51))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-09-09
Project End
2008-07-31
Budget Start
2003-09-09
Budget End
2004-07-31
Support Year
1
Fiscal Year
2003
Total Cost
$341,289
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Gagnon, Louis; YĆ¼cel, Meryem A; Dehaes, Mathieu et al. (2012) Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage 59:3933-40
Mesquita, R C; Huppert, T J; Boas, D A (2009) Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex. Phys Med Biol 54:175-85
Huppert, Theodore J; Allen, Monica S; Diamond, Solomon G et al. (2009) Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model. Hum Brain Mapp 30:1548-67
Huppert, Theodore J; Jones, Phill B; Devor, Anna et al. (2009) Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. J Biomed Opt 14:044038
Diamond, Solomon Gilbert; Perdue, Katherine L; Boas, David A (2009) A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation. Math Biosci 220:102-17
Gagnon, Louis; Gauthier, Claudine; Hoge, Rick D et al. (2008) Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system. J Biomed Opt 13:054019
Huppert, Theodore J; Diamond, Solomon G; Boas, David A (2008) Direct estimation of evoked hemoglobin changes by multimodality fusion imaging. J Biomed Opt 13:054031
Boas, David A; Jones, Stephanie R; Devor, Anna et al. (2008) A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage 40:1116-29
Huppert, Theodore J; Allen, Monica S; Benav, Heval et al. (2007) A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation. J Cereb Blood Flow Metab 27:1262-79
Huppert, Theodore J; Hoge, Rick D; Dale, Anders M et al. (2006) Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging. J Biomed Opt 11:064018

Showing the most recent 10 out of 22 publications