Osteoarthritis (OA) is an enormous clinical problem and worldwide cause of disability. Development of new therapies for OA is hampered by a lack of sensitive imaging tests that respond to changes in disease status. Recently FDA and CE approved clinical knee 7T MRI has the potential to add sensitivity and specificity to advanced MRI biomarkers of OA progression. This project will compare changes seen at 3T and 7T across two different vendors systems and assess the potential for 7T MRI to improve our ability to study and develop new disease- modifying therapies. This study will enhance future studies and clinical exams at 7T and can be used to improve routine 3T MRI though machine learning reconstruction and enhanced understanding of OA disease mechanisms. Understanding the relative strengths of 3T and 7T MRI in this important clinical application is critical to developing new disease-modifying treatments for patients with OA.

Public Health Relevance

Osteoarthritis affects more than half of the population during their lives and is the leading cause of disability worldwide. Diagnostic imaging of osteoarthritis is often limited to x-ray, but more sensitive and specific imaging is a critical need for development of disease-modifying treatments. This work aims to develop novel 3D imaging approaches using 3T and 7T magnetic resonance imaging (MRI), to quantitatively assess joint health across different tissues in osteoarthritis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
2R01EB002524-14A1
Application #
10071340
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Liu, Guoying
Project Start
2003-09-20
Project End
2024-02-29
Budget Start
2020-06-15
Budget End
2021-02-28
Support Year
14
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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