This proposal, Interactive Real-time fMRI at High Field with Automatic Classification of Activation Patterns is submitted in response to RFA EB-03-007. The objective of this application is to further develop highly sensitive multi-echo pulse sequences with parallel imaging data acquisition and compensation of susceptibility artifacts at high magnetic field (4 Tesla), and to design real-time data analysis methods that allow automatic classification of brain activation patterns in terms of underlying cognitive processes. Feasibility of this methodology has already been shown in pilot studies at 1.5 and 4 Tesla. A secondary goal is to validate this methodology with interactive experimental paradigms by characterizing neural correlates of cognitive and emotional processes in individual subjects. This novel real-time fMRI methodology is applicable to a wide range of neuroscience research and to a variety of neuro-psychiatric conditions in which pathology of the amygdala is implicated, such as unipolar and bipolar depression, anxiety, schizophrenia, psychopathy and social phobia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002618-03
Application #
6803543
Study Section
Special Emphasis Panel (ZRG1-SRB (51))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-09-30
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$255,792
Indirect Cost
Name
University of New Mexico
Department
Psychiatry
Type
Schools of Medicine
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
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