Coronary artery disease is the leading cause of death in the United States. The overall objective of the proposed project is to develop, optimize, and validate a high resolution magnetic resonance (MR) imaging protocol to evaluate coronary artery disease noninvasively. The long-term goal is to provide a noninvasive screening test for coronary artery disease. This test could potentially be combined with other hemodynamic, functional, and metabolic studies available from MRI to form a comprehensive examination of coronary artery disease for improved patient care and cost savings. The specific goal of the project is to improve the spatial resolution, speed, and signal intensity of coronary artery images. We will acquire the images on a 3.0-Tesla scanner which can generate images with high signal intensity than conventional 1.5-Tesla systems. We will develop and validate the coronary artery imaging techniques on 3.0T and compare with 1.5T to verify the improved performance. Finally, patients will be studied to determine the capability of the new technique in detecting functionally significant coronary artery stenoses by comparing with conventional x-ray angiography. Positive results from this study will provide the foundation for further technical improvements and clinical validation.
The specific aims of the project are:
Aim 1 : To develop a fast coronary artery angiography protocol on 3.0T capable of acquiring high-resolution images to accurately define vessel lumen size Aim 2: To verify that the developed coronary MRA protocol on 3.0T can accurately depict coronary artery stenoses in pigs; image SNR and accuracy of stenosis detection on 3.0T are better than those on 1.
5T Aim 3 : To demonstrate that the developed imaging protocol on 3.0T can accurately detect coronary artery disease in patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB002623-01
Application #
6734096
Study Section
Special Emphasis Panel (ZRG1-SRB (51))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-09-25
Project End
2007-07-31
Budget Start
2003-09-25
Budget End
2004-07-31
Support Year
1
Fiscal Year
2003
Total Cost
$303,195
Indirect Cost
Name
Northwestern University at Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Xie, Guoxi; Bi, Xiaoming; Liu, Jiabin et al. (2016) Three-dimensional coronary dark-blood interleaved with gray-blood (cDIG) magnetic resonance imaging at 3 tesla. Magn Reson Med 75:997-1007
Pang, Jianing; Chen, Yuhua; Fan, Zhaoyang et al. (2016) High efficiency coronary MR angiography with nonrigid cardiac motion correction. Magn Reson Med 76:1345-1353
Chen, David; Sharif, Behzad; Bi, Xiaoming et al. (2016) Quantification of myocardial blood flow using non-electrocardiogram-triggered MRI with three-slice coverage. Magn Reson Med 75:2112-20
Ahlman, Mark A; Raman, Fabio S; Pang, Jianing et al. (2016) Part 2 - Coronary angiography with gadofosveset trisodium: a prospective intra-subject comparison for dose optimization for 100 % efficiency imaging. BMC Cardiovasc Disord 16:58
Ahlman, Mark A; Raman, Fabio S; Penzak, Scott R et al. (2015) Part 1 - Coronary angiography with gadofosveset trisodium: a prospective feasibility study evaluating injection techniques for steady-state imaging. BMC Cardiovasc Disord 15:177
Chen, David; Sharif, Behzad; Dharmakumar, Rohan et al. (2015) Quantification of myocardial blood flow using non-ECG-triggered MR imaging. Magn Reson Med 74:765-71
Nguyen, Christopher; Fan, Zhaoyang; Xie, Yibin et al. (2014) In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 16:68
Pang, Jianing; Sharif, Behzad; Fan, Zhaoyang et al. (2014) ECG and navigator-free four-dimensional whole-heart coronary MRA for simultaneous visualization of cardiac anatomy and function. Magn Reson Med 72:1208-17
Chen, David; Sharif, Behzad; Dharmakumar, Rohan et al. (2014) Improved quantification of myocardial blood flow using highly constrained back projection reconstruction. Magn Reson Med 72:749-55
Sharif, Behzad; Dharmakumar, Rohan; Arsanjani, Reza et al. (2014) Non-ECG-gated myocardial perfusion MRI using continuous magnetization-driven radial sampling. Magn Reson Med 72:1620-8

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