Conventional magnetic resonance imaging has good sensitivity for detecting breast lesions but its specificity is inadequate. High spectral and spatial resolution (HISS) Magnetic Resonance Imaging (MRI) of water and fat signals is a new approach that may increase both sensitivity and specificity of MRI. HiSS MRI equals or exceeds the spatial resolution of conventional MRI and provides detailed spectra of the water and fat in each voxel. The water and fat lineshapes are analyzed to produce images proportional to resonance linewidth, peak height, integral, changes following contrast media injection, and other parameters. HiSS MRI images are acquired with clinically acceptable run times using echo-planar spectroscopic methods. Previous work in this laboratory demonstrated quantitatively that contrast, edge delineation, and sensitivity to contrast agents in breast images derived from HiSS data are improved compared to conventional images. Although these results are promising, the methods used for data acquisition and processing were not optimal. In addition, there has been very limited experience with imaging small breast lesions. Therefore, the present application proposes technical improvements to HiSS and tests of the method for imaging small breast lesions in women who are later biopsied. Technical improvements to HiSS imaging: Data acquisition rates will be increased by sampling two lines of k-space in parallel. Improved data filtering methods and corrections for errors in k-space sampling will be implemented. Methods for generating images of Fourier components of the water resonance in each voxel will be developed and tested. Scans of small breast lesions: HiSS will be incorporated into the clinical breast imaging protocol used at the University of Chicago. In women who are known to have small breast lesions based on mammographic findings, HiSS scans will be performed before contrast media injection, at 3 minutes after contrast media injection, and at 20 minutes after injection. Images derived from HiSS datasets will be quantitatively compared to conventional images to determine whether HiSS improves sensitivity to features of lesions that are associated with malignancies, such as spiculations and inhomogeneous contrast media uptake. In addition the experiments will determine whether addition of HiSS imaging to clinical scans significantly improves sensitivity and specificity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB003108-02
Application #
6799275
Study Section
Special Emphasis Panel (ZRG1-SRB (51))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-09-15
Project End
2007-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
2
Fiscal Year
2004
Total Cost
$308,813
Indirect Cost
Name
University of Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Dhyani, Anita H; Fan, Xiaobing; Leoni, Lara et al. (2013) Empirical mathematical model for dynamic manganese-enhanced MRI of the murine pancreas for assessment of ?-cell function. Magn Reson Imaging 31:508-14
Wood, Abbie M; Medved, Milica; Bacchus, Ian D et al. (2013) Classification of breast lesions pre-contrast injection using water resonance lineshape analysis. NMR Biomed 26:569-77
Medved, Milica; Karczmar, Gregory S; Newstead, Gillian M (2012) Do we really need contrast agents? Eur J Radiol 81 Suppl 1:S99-100
Medved, Milica; Fan, Xiaobing; Abe, Hiroyuki et al. (2011) Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images. Acad Radiol 18:1467-74
Medved, Milica; Newstead, Gillian M; Abe, Hiroyuki et al. (2010) Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage. Magn Reson Imaging 28:16-21
Medved, Milica; Ivancevic, Marko K; Olopade, Olufunmilayo I et al. (2010) Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE). Magn Reson Med 63:1557-63
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Foxley, Sean; Fan, Xiaobing; Mustafi, Devkumar et al. (2009) Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images. Magn Reson Med 61:291-8
Jansen, Sanaz A; Paunesku, Tatjana; Fan, Xiaobing et al. (2009) Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model. Radiology 253:399-406

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